Document Detail

Analysis of patients with false negative mammography and symptomatic breast carcinoma.
MedLine Citation:
PMID:  17929256     Owner:  NLM     Status:  MEDLINE    
AIM: False-negative mammograms may result in a delay in breast carcinoma diagnosis and have important implications for patient care. In this study, the characteristics of symptomatic patients with false-negative mammograms were analysed. METHODS: Patients with symptomatic breast carcinoma were identified over a 10-year period (1994-2004). One hundred and twenty-four patients had false-negative preoperative mammograms and 1241 patients had abnormal preoperative mammograms. Clinical presentation, diagnostic methods and pathology were analysed. False-negative mammograms were reviewed by a specialist breast radiologist. RESULTS: Following retrospective review, 42% of false-negative mammograms were re-categorised as suspicious. The most commonly misinterpreted lesion was architectural distortion/asymmetrical density. Adjuvant ultrasound, where performed (n = 27), raised the level of suspicion in 93% of cases. Patients with false-negative mammograms were more likely to be younger (P < 0.0001), present with nipple discharge (P = 0.002) and have smaller tumours (P < 0.0001). Their tumours were more frequently located outside the upper outer quadrant (P = 0.002). False-negative mammography led to a delay in diagnosis of >2 months in 12 patients. CONCLUSION: Symptomatic patients with false-negative mammograms often demonstrate definite abnormalities on imaging, the most common of which is architectural distortion/asymmetrical density. Those at particular risk were younger patients, those with nipple discharge, and patients with lesions located outside the upper outer quadrant.
Ian G Murphy; Mary F Dillon; Ann O' Doherty; Enda W McDermott; Gabrielle Kelly; Niall O'Higgins; Arnold D K Hill
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of surgical oncology     Volume:  96     ISSN:  0022-4790     ISO Abbreviation:  J Surg Oncol     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-16     Completed Date:  2007-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0222643     Medline TA:  J Surg Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  457-63     Citation Subset:  IM    
Department of Surgery, St Vincent's University Hospital, Elm Park, Dublin, Ireland.
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MeSH Terms
Age Factors
Breast Neoplasms / pathology,  radiography*
False Negative Reactions*
Middle Aged
Retrospective Studies
Ultrasonography, Mammary

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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