| Analysis of the pathological lesions of the lung in a mouse model of cutaneous infection with Streptococcus pyogenes. | |
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MedLine Citation:
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PMID: 22243779 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Invasive diseases such as toxic shock syndrome caused by Streptococcus pyogenes (S. pyogenes) are re-emerging infectious diseases. The mechanism of pathogenesis is not completely understood although the virulence of this organism has been analyzed using animal model systems, particularly using mice. The analysis of the progression of infection, however, is difficult. Computed tomography (CT) scanning is an extremely powerful technique that we applied to the mouse model of cutaneous infection with S. pyogenes. Two or three days after subcutaneous administration of bacteria, high density reticular areas were detected in the lung by CT. Histopathological examination of the lung was performed to examine the results of CT. Increased numbers of cytokeratin-positive epithelial cells, probably alveolar type II epithelial cells, were detected but no remarkable increase of inflammatory cell infiltrates was observed. Our results show that the pathological lesions of the lung in this model, wherein relatively few numbers of neutrophils were in the alveoli, are well correlated with the lung of a part of streptococcal toxic shock syndrome patients. Therefore, CT may be useful in assessing the progression of S. pyogenes infection, particularly in the pathological lesions of the lung in this model. |
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Authors:
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Masaaki Minami; Sayaka Sobue; Masatoshi Ichihara; Tadao Hasegawa |
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Publication Detail:
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Type: Journal Article Date: 2011-11-28 |
Journal Detail:
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Title: Pathology international Volume: 62 ISSN: 1440-1827 ISO Abbreviation: Pathol. Int. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9431380 Medline TA: Pathol Int Country: Australia |
Other Details:
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Languages: eng Pagination: 99-104 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Pathology International © 2011 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
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Department of Bacteriology, Nagoya City University Graduate School of Medical Sciences, Nagoya Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Japan. |
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