Document Detail

Analysis of paranasal sinus development and anatomical variations: a CT genetic study in twins.
MedLine Citation:
PMID:  17403223     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine if anatomical variations in the paranasal sinuses of twins are the result of genetic or environmental influences. STUDY DESIGN: A prospective, observational study. SETTING: An academic hospital in Brussels, Belgium. PARTICIPANTS: Twenty-five volunteer twins (17 identical twins and eight non-identical twins). Of the identical twins, six were both female and 11 both male. The mean age was 40.6 years (18-49). Of the non-identical twins, one pair was female and seven were male. The mean age was 39.6 years (25-48). MAIN OUTCOME MEASURES: The CT-scan similarity in anatomical structures (frontal cells, agger nasi cells, concha bullosa, infraorbital cells and changes in the shape of the lamina orbitalis), and the intranasal and paranasal sinus morphology was compared between the twins. RESULTS: Among the studied variables, there was no statistically significant difference between the two twin groups (Fisher's exact test, P > 0.05). Regarding combine-studied parameters, there were no identical CT scans in the twins. However, a tendency of non-genetic influence existed in the development of frontal cell type III and IV, and infraorbital cells, as well as a liability of genetic influence in the presence of concha bullosa. CONCLUSION: In this study, the differences in anatomical structure of the paranasal sinuses between identical and non-identical twin pairs were not statistically significant. This indicates that environmental factors are more significant than genetic ones in the development of anatomical variations in paranasal sinus anatomy.
S Chaiyasate; I Baron; P Clement
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Publication Detail:
Type:  Journal Article; Twin Study    
Journal Detail:
Title:  Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery     Volume:  32     ISSN:  1749-4478     ISO Abbreviation:  -     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-03     Completed Date:  2007-07-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101247023     Medline TA:  Clin Otolaryngol     Country:  England    
Other Details:
Languages:  eng     Pagination:  93-7     Citation Subset:  IM    
Department of Otolaryngology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
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MeSH Terms
Diseases in Twins / genetics*
Genetic Predisposition to Disease / genetics
Middle Aged
Nasal Septum / abnormalities,  radiography
Paranasal Sinuses / abnormalities*,  radiography*
Prospective Studies
Social Environment
Tomography, X-Ray Computed*
Turbinates / abnormalities,  radiography
Twins, Dizygotic / genetics
Twins, Monozygotic / genetics

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