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Analysis of oxidative status and biochemical parameters in adult patients with sickle cell anemia treated with hydroxyurea, Ceará, Brazil.
MedLine Citation:
PMID:  23049297     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Sickle cell anemia is a hemoglobinopathy caused by a mutation that results in the production of an abnormal hemoglobin molecule, hemoglobin S (Hb S). This is responsible for profound physiological changes, such as the sickling of red blood cells. Several studies have shown that hydroxyurea protects against vaso-occlusive crises.
OBJECTIVE: The aim of this study was to evaluate the oxidative stress associated with biochemical parameters in patients with sickle cell anemia treated with hydroxyurea.
METHODS: The study was conducted with 20 male and 25 female patients at the Hospital Universitário Walter Cantídio. The patients were divided into two groups: a study group (n = 12), patients with sickle cell anemia who were receiving hydroxyurea and a control group (n = 33) of sickle cell anemia patients not submitted to hydroxyurea treatment. The biochemical parameters analyzed were ferritin, transferrin, and serum iron. Glutathione was measured in its reduced form to analyze the oxidative state.
RESULTS: The results showed insignificant increases in the levels of serum iron, transferrin and ferritin in patients treated with hydroxyurea when compared with those who did not take the medication. However, the glutathione levels were significantly higher in patients taking hydroxyurea than in controls.
CONCLUSIONS: These results indicate that hydroxyurea possibly acts as an antioxidant by increasing glutathione levels.
Authors:
Paulo Florentino Teixeira Neto; Romélia Pinheiro Gonçalves; Darcielle Bruna Dias Elias; Cleiton Pinheiro de Araújo; Hemerson Iury Ferreira Magalhães
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Revista brasileira de hematologia e hemoterapia     Volume:  33     ISSN:  1806-0870     ISO Abbreviation:  Rev Bras Hematol Hemoter     Publication Date:  2011  
Date Detail:
Created Date:  2012-10-10     Completed Date:  2012-10-10     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101220159     Medline TA:  Rev Bras Hematol Hemoter     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  207-10     Citation Subset:  -    
Affiliation:
Pathology Department, Universidade Federal do Ceará - UFC, Fortaleza, CE, Brazil.
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