Document Detail

Analysis of nonlinear coupled diffusion of oxygen and lactic acid in intervertebral discs.
MedLine Citation:
PMID:  16502654     Owner:  NLM     Status:  MEDLINE    
The transport of oxygen and lactate (i.e., lactic acid) in the human intervertebral disc was investigated accounting for the measured coupling between species via the pH level in the tissue. Uncoupled cases were also analyzed to identify the extent of the effect of such coupling on the solute gradients across the disc. Moreover, nonlinear lactic production rate versus lactic concentration and oxygen consumption rate versus oxygen concentration were considered. The nonlinear coupled diffusion equations were solved using an in-house finite element program and an axisymmetric model of the disc with distinct nucleus and anulus regions. A pseudotransient approach with a backward integration scheme was employed to improve convergence. Coupled simulations influenced the oxygen concentration and lactic acid concentration throughout the disc, in particular the gradient of concentrations along the disc mid-height to the nucleus-anulus boundary where the solutes reached their most critical values; minimum for the oxygen tension and maximum for the lactate. Results suggest that for realistic estimates of nutrient and metabolite gradients across the disc, it could be important to take into account the coupling between the rates of synthesis and overall local metabolite/nutrient concentration.
D Mokhbi Soukane; A Shirazi-Adl; J P G Urban
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomechanical engineering     Volume:  127     ISSN:  0148-0731     ISO Abbreviation:  J Biomech Eng     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2006-02-28     Completed Date:  2006-05-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909584     Medline TA:  J Biomech Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1121-6     Citation Subset:  IM    
Department of Mechanical Engineering, Ecole Polytechnique, Montreal, Québec, Canada.
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MeSH Terms
Computer Simulation
Intervertebral Disk / chemistry*,  metabolism*
Lactic Acid / chemistry*,  metabolism*
Models, Biological*
Nonlinear Dynamics
Oxygen / chemistry*,  metabolism*
Reg. No./Substance:
50-21-5/Lactic Acid; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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