| Analysis of neuronal nitric oxide synthase expression and increasing astrogliosis in the brain of senescence-accelerated-prone 8 mice. | |
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MedLine Citation:
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PMID: 20707635 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The senescence-accelerated mouse (SAM) is an autogenic senile murine model characterized by early cognitive impairment and age-related deterioration of learning and memory. The present study investigated the alternations of neuronal nitric oxide synthase (nNOS) expression in frontal cortex and hippocampus in the aging process of SAM-prone 8 (SAMP8) and SAM-resistant 1 (SAMR1) mice. The results demonstrated that the expression of nNOS was upregulated in the frontal cortex, but downregulated in the hippocampus in SAMP8. Further, age-related increases of astrogliosis were seen in the cortex and hippocampi of aged SAMP8 and SAMR1, as revealed by the expression of the astrocyte specific marker, glial fibrillary acidic protein (GFAP). Indeed, astrogliosis in aged SAMP8 was significantly greater than that of aged SAMR1. Our results suggest the possibility of a correlation between the downregulation of nitric oxide (NO) in the hippocampus and reported learning and memory deficits in SAMP8. However, the toxic effects of NO and age-related increases of astrogliosis, may have contributed to abnormal alterations in metabolism and neurochemical mechanisms in aged SAMP8. |
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Authors:
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Shu Han; John A Rudd; Zhi Ying Hu; Lihong Zhang; David T Yew; Marong Fang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The International journal of neuroscience Volume: 120 ISSN: 1563-5279 ISO Abbreviation: Int. J. Neurosci. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-16 Completed Date: 2010-12-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0270707 Medline TA: Int J Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 602-8 Citation Subset: IM |
Affiliation:
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Institute of Anatomy and Cell Biology, Medical College, Zhejiang University, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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genetics,
metabolism* Animals Brain / metabolism* Cerebral Cortex / metabolism Glial Fibrillary Acidic Protein / metabolism Gliosis / metabolism* Hippocampus / metabolism Male Memory Mice Mice, Mutant Strains Nitric Oxide / metabolism Nitric Oxide Synthase Type I / biosynthesis*, genetics |
| Chemical | |
Reg. No./Substance:
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0/Glial Fibrillary Acidic Protein; 10102-43-9/Nitric Oxide; EC 1.14.13.39/Nitric Oxide Synthase Type I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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