| Analysis of the modal hypothesis of Ca2+-dependent inactivation of L-type Ca2+ channels. | |
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MedLine Citation:
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PMID: 15936868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A kinetic model of Ca2+-dependent inactivation (CDI) of L-type Ca2+ channels was developed. The model is based on the hypothesis that postulates the existence of four short-lived modes with lifetimes of a few hundreds of milliseconds. Our findings suggest that the transitions between the modes is primarily determined by the binding of Ca2+ to two intracellular allosteric sites located in different motifs of the CI region, which have greatly differing binding rates for Ca2+ (different k(on)). The slow-binding site is controlled by local Ca2+ near a single open channel that is consistent with the "domain" CDI model, and Ca2+ binding to the fast-binding site(s) depends on Ca2+ arising from distant sources that is consistent with the "shell" CDI model. The model helps to explain numerous experimental findings that are poorly understood so far. |
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Authors:
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Nick I Markevich; Oleg Y Pimenov; Yury M Kokoz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biophysical chemistry Volume: 117 ISSN: 0301-4622 ISO Abbreviation: Biophys. Chem. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-22 Completed Date: 2005-12-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0403171 Medline TA: Biophys Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 173-90 Citation Subset: IM |
Affiliation:
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Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow 142290, Russia. Nikolai.Markevitch@jefferson.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Calcium
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chemistry,
physiology* Calcium Channels, L-Type / chemistry, physiology* Ion Channel Gating / physiology Kinetics Membrane Potentials / physiology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channels, L-Type; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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