Document Detail


Analysis of the modal hypothesis of Ca2+-dependent inactivation of L-type Ca2+ channels.
MedLine Citation:
PMID:  15936868     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A kinetic model of Ca2+-dependent inactivation (CDI) of L-type Ca2+ channels was developed. The model is based on the hypothesis that postulates the existence of four short-lived modes with lifetimes of a few hundreds of milliseconds. Our findings suggest that the transitions between the modes is primarily determined by the binding of Ca2+ to two intracellular allosteric sites located in different motifs of the CI region, which have greatly differing binding rates for Ca2+ (different k(on)). The slow-binding site is controlled by local Ca2+ near a single open channel that is consistent with the "domain" CDI model, and Ca2+ binding to the fast-binding site(s) depends on Ca2+ arising from distant sources that is consistent with the "shell" CDI model. The model helps to explain numerous experimental findings that are poorly understood so far.
Authors:
Nick I Markevich; Oleg Y Pimenov; Yury M Kokoz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biophysical chemistry     Volume:  117     ISSN:  0301-4622     ISO Abbreviation:  Biophys. Chem.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-22     Completed Date:  2005-12-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0403171     Medline TA:  Biophys Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  173-90     Citation Subset:  IM    
Affiliation:
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow 142290, Russia. Nikolai.Markevitch@jefferson.edu
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MeSH Terms
Descriptor/Qualifier:
Calcium / chemistry,  physiology*
Calcium Channels, L-Type / chemistry,  physiology*
Ion Channel Gating / physiology
Kinetics
Membrane Potentials / physiology
Time Factors
Chemical
Reg. No./Substance:
0/Calcium Channels, L-Type; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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