| Analysis on migration and activation of live macrophages on transparent flat and nanostructured titanium. | |
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MedLine Citation:
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PMID: 21232636 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The immunotoxicity of implanted nanostructured titanium is a paramount issue for vascular, dental and orthopedic applications. However, it has hitherto been unclear whether implanted surface nanostructures can inhibit inflammatory response. Herein, macrophage activation, as evidence of migration, on transparent flat and nanostructured titanium correlated with pro-inflammatory protein synthesis and cytokine release. Through the real-time monitoring of initial cytoskeleton variations, this study identified that macrophage movement was restricted on nanostructured titanium compared to flat titanium surfaces. Furthermore, nanostructured titanium elicited secretion of fewer pro-inflammatory enzyme molecules and cytokines, as well as reduced nitric oxide production. All results collectively indicated that initial macrophage activation can be mitigated by nanoscale surface topography alone, without modification of surface chemistry or stiffness. |
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Authors:
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Soyoung Lee; Jungil Choi; Sangwon Shin; Yeon-Min Im; Jonghan Song; Sang Soo Kang; Tae-Hyun Nam; Thomas J Webster; Sang-Hyun Kim; Dongwoo Khang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-11 |
Journal Detail:
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Title: Acta biomaterialia Volume: - ISSN: 1878-7568 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101233144 Medline TA: Acta Biomater Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Pharmacology, Kyungpook National University Medical School, Daegu, 700-422, South Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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