Document Detail

Analysis of the microenvironment necessary for engraftment: role of the vascular smooth muscle-like stromal cells.
MedLine Citation:
PMID:  11177608     Owner:  NLM     Status:  MEDLINE    
This is a review of recent data concerning the phenotype of human and murine stroma, as grown in long-term cultures. Using data on cytoskeletal and extracellular matrix protein expression, a sequential model of differentiation from mesenchymal (stem) cells to vascular-smooth muscle-like stromal cells is proposed. This model would apply, at least in the mouse, to stromal cells generated from different sites of hematopoiesis (bone marrow, fetal liver, spleen, and yolk sac). The in vivo counterparts of vascular-smooth muscle-like stromal cells in the different sites of definitive hematopoiesis are discussed.
P Charbord; J P Rémy-Martin; E Tamayo; G Bernard; A Keating; B Péault
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of hematotherapy & stem cell research     Volume:  9     ISSN:  1525-8165     ISO Abbreviation:  J. Hematother. Stem Cell Res.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-06-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100892915     Medline TA:  J Hematother Stem Cell Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  935-43     Citation Subset:  IM    
ETS de Franche Comté, Besançon, France.
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MeSH Terms
Graft Survival / physiology*
Hematopoietic Stem Cell Transplantation
Muscle, Smooth, Vascular / cytology
Stromal Cells / cytology*,  metabolism,  physiology

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