Document Detail

Analysis of mean transit time of contrast medium in ruptured and unruptured arteriovenous malformations: a digital subtraction angiographic study.
MedLine Citation:
PMID:  12970520     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: To clarify hemodynamic risk factors for hemorrhage in arteriovenous malformations (AVMs), the mean transit time (MTT) of feeding arteries and draining veins in AVMs with and without hemorrhage was measured and analyzed. METHODS: Morphological features such as the number and diameter of draining and feeding vessels and the AVM nidus volume were evaluated in 30 patients with supratentorial AVMs. The MTT of feeding arteries and draining veins was measured with the use of time-density curves obtained by digital subtraction angiography. The correlation between hemorrhage and morphology and hemorrhage and MTT was analyzed statistically. RESULTS: The nidus volume was not significantly different between hemorrhagic and nonhemorrhagic AVMs. However, between ruptured and unruptured AVMs there was a significant difference in the mean number of draining veins (1.5+/-0.69 versus 2.3+/-0.50; P=0.006), the MTT of the feeding artery (1.10+/-0.24 versus 1.62+/-0.55; P=0.03), and the ratio of the MTT of the draining to the feeding vessels (1.71+/-0.43 versus 1.05+/-0.07; P<0.001). CONCLUSIONS: A high ratio of the MTT of draining veins to feeding arteries suggests disequilibrium between nidal inflow and outflow. The consequent increased pressure in the draining vein may contribute to the development of AVM hemorrhage.
Tatemi Todaka; Jun-ichiro Hamada; Yutaka Kai; Motohiro Morioka; Yukitaka Ushio
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2003-09-11
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  34     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-03     Completed Date:  2003-11-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2410-4     Citation Subset:  IM    
Department of Neurosurgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860-8556, Japan.
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MeSH Terms
Angiography, Digital Subtraction / methods*
Blood Flow Velocity
Cerebral Arteries / physiopathology,  radiography
Cerebral Hemorrhage / physiopathology,  radiography*
Cerebral Veins / physiopathology,  radiography
Contrast Media / administration & dosage*
Intracranial Arteriovenous Malformations / physiopathology,  radiography*
Middle Aged
Predictive Value of Tests
Rupture, Spontaneous*
Time Factors
Reg. No./Substance:
0/Contrast Media

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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