Document Detail

Analysis of limb reduction defects in babies exposed to chorionic villus sampling.
MedLine Citation:
PMID:  7909100     Owner:  NLM     Status:  MEDLINE    
In 1991 we reported a cluster of babies with limb abnormalities and suggested that chorionic villus sampling (CVS) was aetiologically associated with these defects. To address the issue more objectively, we have assessed reported limb reduction defects in 75 babies exposed to CVS in utero. 13 babies had an absent limb or a defect through the humerus or femur; 9 had defects through the radius or tibia; 22 defects of the carpus, tarsus, metacarpus, or metatarsus; 25 defects of the digits; and 6 defects of the terminal phalanx or nail only. There was a strong correlation between the severity of the defects and the duration of gestation when CVS was done. The median gestational age at CVS ranged from 56 (range 49-65) postmenstrual days for the most severe category to 72 (51-98) days for the least severe. The relation was seen for both isolated limb defects and for cases with oromandibular-limb hypogenesis syndromes. This relation is further evidence that CVS has an aetiological role in some limb reduction anomalies.
H V Firth; P A Boyd; P F Chamberlain; I Z MacKenzie; G M Morriss-Kay; S M Huson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  343     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-05-19     Completed Date:  1994-05-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1069-71     Citation Subset:  AIM; IM    
Oxford Regional Genetics Service, Churchill Hospital, UK.
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MeSH Terms
Abnormalities, Multiple / etiology*
Arm / abnormalities*
Chorionic Villi Sampling / adverse effects*
Gestational Age
Leg / abnormalities*
Pregnancy Trimester, Third
Comment In:
Lancet. 1994 Aug 13;344(8920):476   [PMID:  7914585 ]
Lancet. 1994 Jul 2;344(8914):66   [PMID:  7912338 ]

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