| Analysis of limb reduction defects in babies exposed to chorionic villus sampling. | |
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MedLine Citation:
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PMID: 7909100 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 1991 we reported a cluster of babies with limb abnormalities and suggested that chorionic villus sampling (CVS) was aetiologically associated with these defects. To address the issue more objectively, we have assessed reported limb reduction defects in 75 babies exposed to CVS in utero. 13 babies had an absent limb or a defect through the humerus or femur; 9 had defects through the radius or tibia; 22 defects of the carpus, tarsus, metacarpus, or metatarsus; 25 defects of the digits; and 6 defects of the terminal phalanx or nail only. There was a strong correlation between the severity of the defects and the duration of gestation when CVS was done. The median gestational age at CVS ranged from 56 (range 49-65) postmenstrual days for the most severe category to 72 (51-98) days for the least severe. The relation was seen for both isolated limb defects and for cases with oromandibular-limb hypogenesis syndromes. This relation is further evidence that CVS has an aetiological role in some limb reduction anomalies. |
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Authors:
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H V Firth; P A Boyd; P F Chamberlain; I Z MacKenzie; G M Morriss-Kay; S M Huson |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Lancet Volume: 343 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1994 Apr |
Date Detail:
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Created Date: 1994-05-19 Completed Date: 1994-05-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1069-71 Citation Subset: AIM; IM |
Affiliation:
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Oxford Regional Genetics Service, Churchill Hospital, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Multiple
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etiology* Arm / abnormalities* Chorionic Villi Sampling / adverse effects* Female Gestational Age Humans Leg / abnormalities* Pregnancy Pregnancy Trimester, Third Syndrome |
| Comments/Corrections | |
Comment In:
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Lancet. 1994 Aug 13;344(8920):476
[PMID:
7914585
]
Lancet. 1994 Jul 2;344(8914):66 [PMID: 7912338 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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