Document Detail


Analysis of licking responses in rats: effects of cholecystokinin and bombesin.
MedLine Citation:
PMID:  6849686     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A detailed analysis of the licking response of rats to milk was made. The effects of cholecystokinin (CCK) and bombesin (BBS) on the consummatory response were compared. The normal licking response pattern was found not to change as the meal progressed; no predictor was found to indicate when the meal would terminate. Licks normally occurred at about six per second, but there were a few licks that occurred at about three per second, with no licking occurring in the intermediate range; thus a distinctive bimodal frequency distribution of the interlick interval was formed. Cholecystokinin was found to reduce the intake of milk and the related licking indexes as expected, but it also induced an unusual licking pattern: The contact duration was shortened, the interlick interval was lengthened, and there was an increase in the proportion of licks with long interlick intervals, the effects that accentuated the bimodality of the distribution of interlick intervals. Bombesin reduced the intake and the related licking indexes as expected; however, it did not induce any unusual licking characteristics as seen with CCK at comparable effective doses. The CCK effect may be mediated partially by a change in the motor aspect of the consummatory response; however, BBS reduced intake by simply decreasing the number of licks and shortening the intake duration.
Authors:
S Hsiao; R Spencer
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  97     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-07-15     Completed Date:  1983-07-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  234-45     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bombesin / pharmacology*
Cholecystokinin / pharmacology*,  physiology
Dose-Response Relationship, Drug
Feeding Behavior / drug effects*
Male
Milk
Minicomputers
Peptides / pharmacology*
Rats
Satiation / physiology
Grant Support
ID/Acronym/Agency:
AM 25381-02/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Peptides; 31362-50-2/Bombesin; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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