| Analysis of the inhibitory mechanism of D-allose on MOLT-4F leukemia cell proliferation. | |
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MedLine Citation:
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PMID: 19393559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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D-Allose, the C-3 epimer of D-glucose, is one of the rare sugars found in nature. In the present study, we have elucidated for the first time that various leukemia cell lines have different susceptibility to anti-proliferative activity of D-allose, and that this difference is related to the difference in induction of thioredoxin interacting protein (TXNIP) expression. We examined 5 leukemia cell lines (MOLT-4F, IM-9, HL-60, BALL-1 and Daudi), and found that MOLT-4F (T-cell lymphoblastic leukemia) had the highest susceptibility to D-allose, and that Daudi (Burkitt's lymphoma) had the lowest. D-Allose significantly slowed the cell cycle progression without causing apoptosis of MOLT-4F cells. Intracellular TXNIP expression was specifically and markedly enhanced in MOLT-4F cells by D-allose treatment, and subsequent increase of p27(kip1), a cell cycle inhibitor, was observed. On the other hand, D-allose did not increase TXNIP and p27(kip1) levels at all in Daudi cells. These results indicate that D-allose suppresses MOLT-4F cell proliferation possibly by the inhibition of cell cycle progression via induction of TXNIP expression. |
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Authors:
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Yuko Hirata; Madoka Saito; Ikuko Tsukamoto; Fuminori Yamaguchi; Li Sui; Kazuyo Kamitori; Youyi Dong; Eisuke Uehara; Ryoji Konishi; Najma Janjua; Masaaki Tokuda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of bioscience and bioengineering Volume: 107 ISSN: 1347-4421 ISO Abbreviation: J. Biosci. Bioeng. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-27 Completed Date: 2009-07-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888800 Medline TA: J Biosci Bioeng Country: Japan |
Other Details:
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Languages: eng Pagination: 562-8 Citation Subset: IM |
Affiliation:
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Department of Cell Physiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle
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drug effects* Cell Cycle Proteins / metabolism* Cell Line, Tumor Cell Proliferation / drug effects Dose-Response Relationship, Drug Glucose / administration & dosage* Humans Leukemia / metabolism*, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; 50-99-7/Glucose; 6038-51-3/allose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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