| Analysis in Drosophila melanogaster of the interaction between sex combs reduced and extradenticle activity in the determination of tarsus and arista identity. | |
| | |
MedLine Citation:
|
PMID: 9725838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Sex Combs Reduced (SCR) activity is proposed to be required cell nonautonomously for determination of tarsus identity, and Extradenticle (EXD) activity is required cell autonomously for determination of arista identity. Using the ability of Proboscipedia to inhibit the SCR activity required for determination of tarsus identity, we found that loss-of-EXD activity is epistatic to loss-of-SCR activity in tarsus vs. arista determination. This suggests that in the sequence leading to arista determination SCR activity is OFF while EXD activity is ON, and in the sequence leading to tarsus determination SCR activity is ON, which turns EXD activity OFF. Immunolocalization of EXD in early third-instar larval imaginal discs reveals that EXD is localized in the nuclei of antennal imaginal disc cells and localized in the cytoplasm of distal imaginal leg disc cells. We propose that EXD localized to the nucleus suppresses tarsus determination and activates arista determination. We further propose that in the mesodermal adepithelial cells of the leg imaginal discs, SCR is required for the synthesis of a tarsus-inducer that when secreted acts on the ectoderm cells inhibiting nuclear accumulation of EXD, such that tarsus determination is no longer suppressed and arista determination is no longer activated. |
| | |
Authors:
|
A Percival-Smith; D J Hayden |
Related Documents
:
|
2425628 - Creatine uptake, metabolism, and efflux in human monocytes and macrophages. 4027138 - Phenacetin o-deethylase: an activity of a cytochrome p-450 showing genetic linkage with... 11923428 - Spontaneous retinal activity is tonic and does not drive tectal activity during activit... 22431068 - Intracellular signaling mapk pathway after cerebral ischemia-reperfusion injury. 2546548 - Guanine nucleotides stimulate hydrolysis of phosphatidyl inositol bis phosphate in huma... 12626668 - Angiotensin ii stimulates hyperplasia but not hypertrophy in immature ovine cardiomyocy... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Genetics Volume: 150 ISSN: 0016-6731 ISO Abbreviation: Genetics Publication Date: 1998 Sep |
Date Detail:
|
Created Date: 1998-11-05 Completed Date: 1998-11-05 Revised Date: 2010-09-13 |
Medline Journal Info:
|
Nlm Unique ID: 0374636 Medline TA: Genetics Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 189-98 Citation Subset: IM |
Affiliation:
|
Department of Zoology, University of Western Ontario, London, Ontario N6A 5B7, Canada. aperciva@julian.uwo.ca |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals DNA-Binding Proteins / genetics*, metabolism Drosophila Proteins* Drosophila melanogaster / genetics* Epistasis, Genetic Female Homeodomain Proteins* Insect Proteins / genetics* Male Recombination, Genetic Subcellular Fractions / metabolism Tarsus, Animal Transcription Factors / genetics*, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Homeodomain Proteins; 0/Insect Proteins; 0/Sex combs reduced protein, Drosophila; 0/Transcription Factors; 0/extradenticle protein, Drosophila |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Induced chromosomal exchange directs the segregation of recombinant chromatids in mitosis of Drosoph...
Next Document: Van Gogh: a new Drosophila tissue polarity gene.