Document Detail

Analysis in Drosophila melanogaster of the interaction between sex combs reduced and extradenticle activity in the determination of tarsus and arista identity.
MedLine Citation:
PMID:  9725838     Owner:  NLM     Status:  MEDLINE    
Sex Combs Reduced (SCR) activity is proposed to be required cell nonautonomously for determination of tarsus identity, and Extradenticle (EXD) activity is required cell autonomously for determination of arista identity. Using the ability of Proboscipedia to inhibit the SCR activity required for determination of tarsus identity, we found that loss-of-EXD activity is epistatic to loss-of-SCR activity in tarsus vs. arista determination. This suggests that in the sequence leading to arista determination SCR activity is OFF while EXD activity is ON, and in the sequence leading to tarsus determination SCR activity is ON, which turns EXD activity OFF. Immunolocalization of EXD in early third-instar larval imaginal discs reveals that EXD is localized in the nuclei of antennal imaginal disc cells and localized in the cytoplasm of distal imaginal leg disc cells. We propose that EXD localized to the nucleus suppresses tarsus determination and activates arista determination. We further propose that in the mesodermal adepithelial cells of the leg imaginal discs, SCR is required for the synthesis of a tarsus-inducer that when secreted acts on the ectoderm cells inhibiting nuclear accumulation of EXD, such that tarsus determination is no longer suppressed and arista determination is no longer activated.
A Percival-Smith; D J Hayden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genetics     Volume:  150     ISSN:  0016-6731     ISO Abbreviation:  Genetics     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-11-05     Completed Date:  1998-11-05     Revised Date:  2010-09-13    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  189-98     Citation Subset:  IM    
Department of Zoology, University of Western Ontario, London, Ontario N6A 5B7, Canada.
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MeSH Terms
DNA-Binding Proteins / genetics*,  metabolism
Drosophila Proteins*
Drosophila melanogaster / genetics*
Epistasis, Genetic
Homeodomain Proteins*
Insect Proteins / genetics*
Recombination, Genetic
Subcellular Fractions / metabolism
Tarsus, Animal
Transcription Factors / genetics*,  metabolism
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Homeodomain Proteins; 0/Insect Proteins; 0/Sex combs reduced protein, Drosophila; 0/Transcription Factors; 0/extradenticle protein, Drosophila

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