Document Detail

Analysis of human leukocyte antigen HLA-DR beta amino acid sequence in Vogt-Koyanagi-Harada syndrome.
MedLine Citation:
PMID:  2055689     Owner:  NLM     Status:  MEDLINE    
Vogt-Koyanagi-Harada syndrome (VKH) is a systemic disorder involving many organ systems, including the eye, the ear, the skin, and the meninges. One of the important clinical features of the disease is its strong association with histocompatibility antigens HLA-DR4 and HLA-Dw15. To investigate this association at the DNA level, the polymerase chain reaction technique was used. The DR beta 1 DNA sequence was analyzed to determine which part played the most significant role in the disease process. Although the number of patients studied was small, these data showed that these probes were useful in investigating the HLA-DR subtypes related to VKH. All but one patient (19 of 20) had a specific sequence encoding amino acids 70 and 71 of the HLA-DR beta 1 molecule. The data suggest that the sequence that encodes for amino acids 70 and 71 and adjacent ones of the HLA-DR beta 1 molecule could contribute to disease susceptibility.
J Numaga; K Matsuki; K Tokunaga; T Juji; M Mochizuki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  32     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-07-26     Completed Date:  1991-07-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1958-61     Citation Subset:  IM    
Department of Ophthalmology, Tokyo University School of Medicine, Japan.
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MeSH Terms
Amino Acid Sequence
Base Sequence
DNA / analysis
Electrophoresis, Agar Gel
HLA-DR Antigens / genetics*
Histocompatibility Testing
Molecular Sequence Data
Oligonucleotide Probes
Polymerase Chain Reaction
Random Allocation
Uveomeningoencephalitic Syndrome / genetics*,  immunology
Reg. No./Substance:
0/HLA-DR Antigens; 0/Oligonucleotide Probes; 9007-49-2/DNA

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