Document Detail


Analysis of human leukocyte antigen HLA-DR beta amino acid sequence in Vogt-Koyanagi-Harada syndrome.
MedLine Citation:
PMID:  2055689     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vogt-Koyanagi-Harada syndrome (VKH) is a systemic disorder involving many organ systems, including the eye, the ear, the skin, and the meninges. One of the important clinical features of the disease is its strong association with histocompatibility antigens HLA-DR4 and HLA-Dw15. To investigate this association at the DNA level, the polymerase chain reaction technique was used. The DR beta 1 DNA sequence was analyzed to determine which part played the most significant role in the disease process. Although the number of patients studied was small, these data showed that these probes were useful in investigating the HLA-DR subtypes related to VKH. All but one patient (19 of 20) had a specific sequence encoding amino acids 70 and 71 of the HLA-DR beta 1 molecule. The data suggest that the sequence that encodes for amino acids 70 and 71 and adjacent ones of the HLA-DR beta 1 molecule could contribute to disease susceptibility.
Authors:
J Numaga; K Matsuki; K Tokunaga; T Juji; M Mochizuki
Related Documents :
24453849 - Electrochemical reduction of co2 to organic acids by a pd-mwnts gas-diffusion electrode...
8565779 - A comparison of mass balance, pharmacokinetics and disposition of [14c(u)]- and [125i]r...
3525549 - The structure of hemocyanin ii from the horseshoe crab, limulus polyphemus. the amino a...
6336309 - Isolation and nucleotide sequence of a cdna encoding the precursor of mouse nerve growt...
10978749 - Purification and amino acid sequence of a highly insecticidal toxin from the venom of t...
1068479 - Structural studies on protein products of murine chromosome 17: partial amino acid sequ...
1527989 - Azelaic and pimelic acids: metabolic intermediates or artefacts?
12737229 - Effects of dietary protein concentration and specific amino acids on body weight, body ...
8545619 - Stimulation of butyrate absorption in the human rectum in vivo.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  32     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-07-26     Completed Date:  1991-07-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1958-61     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Tokyo University School of Medicine, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Base Sequence
DNA / analysis
Electrophoresis, Agar Gel
HLA-DR Antigens / genetics*
Histocompatibility Testing
Humans
Molecular Sequence Data
Oligonucleotide Probes
Polymerase Chain Reaction
Random Allocation
Uveomeningoencephalitic Syndrome / genetics*,  immunology
Chemical
Reg. No./Substance:
0/HLA-DR Antigens; 0/Oligonucleotide Probes; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Structural and compositional analyses of isolated cone matrix sheaths.
Next Document:  Spectrophotometric quantitation of rhodopsin in the human retina.