| Analysis of histones, histone variants, and their post-translationally modified forms. | |
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MedLine Citation:
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PMID: 18494025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For many years, histones were considered passive structural components of eukaryotic chromatin. Meanwhile it has been proven that histones also participate in gene regulation and repression via post-translational modification. The multitude of these post-translational modifications and the existence of numerous histone variants require particular separation strategies for their analysis, a prerequisite for studying biological processes. The most widely utilized techniques for the separation of histones, namely PAGE, HPCE, RP-HPLC, and hydrophilic Interaction LC, are reviewed here. Problems inherent to the analysis of histones owing to their unique physical and chemical properties along with advantages and shortcomings of particular methods are discussed. |
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Authors:
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Herbert H Lindner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Electrophoresis Volume: 29 ISSN: 0173-0835 ISO Abbreviation: Electrophoresis Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-26 Completed Date: 2008-09-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8204476 Medline TA: Electrophoresis Country: Germany |
Other Details:
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Languages: eng Pagination: 2516-32 Citation Subset: IM |
Affiliation:
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Division of Clinical Biochemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria. herbert.lindner@i-med.ac.at |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Chromatography, Liquid Chromatography, Micellar Electrokinetic Capillary Electrophoresis, Capillary Electrophoresis, Polyacrylamide Gel Genetic Variation Histones / analysis*, genetics Molecular Sequence Data |
| Chemical | |
Reg. No./Substance:
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0/Histones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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