| Analysis of hemodynamics and blood gas in relation to blood ketone body ratio in partially hepatectomized patients. | |
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MedLine Citation:
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PMID: 2553418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A total of 205 studies of hemodynamics and blood gas analyses were performed in relation to hepatic mitochondrial redox state in 23 partially hepatectomized patients. When the blood ketone body ratio (the ratio of acetoacetate to beta-hydroxybutyrate in arterial blood) decreased, that is when the hepatic mitochondrial redox state was reduced, a hyperdynamic state with increased cardiac index, decreased systemic and pulmonary vascular resistance together with decreased oxygen consumption was observed in spite of the increased oxygen availability. Inhibited oxidative metabolism in the Krebs cycle may have resulted in the decreased oxygen consumption and decreased vascular tone. This study supports the concept that the hepatic metabolic derangements due to reduced hepatic mitochondrial redox state may be a factor in the decreased oxygen consumption and hyperdynamic state. |
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Authors:
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T Nakatani; Y Shimahara; K Mori; N Kobayashi; Y Yamaoka; K Kobayashi; K Ozawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes Volume: 21 ISSN: 0014-312X ISO Abbreviation: Eur Surg Res Publication Date: 1989 |
Date Detail:
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Created Date: 1989-11-28 Completed Date: 1989-11-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0174752 Medline TA: Eur Surg Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 205-12 Citation Subset: IM |
Affiliation:
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Trauma and Critical Care Center, Teikyo University School of Medicine, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Gas Analysis* Carcinoma, Hepatocellular / surgery Female Hemodynamics Hepatectomy* Humans Ketone Bodies / blood* Liver Neoplasms / surgery Male Middle Aged Mitochondria, Liver / metabolism* Oxidation-Reduction |
| Chemical | |
Reg. No./Substance:
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0/Ketone Bodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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