Document Detail

Analysis of hemodynamic response with 1/R control on biventricular bypass goat.
MedLine Citation:
PMID:  10816207     Owner:  NLM     Status:  MEDLINE    
A conductance and arterial pressure based method (1/R control) to determine the cardiac output (CO) of a total artificial heart (TAH) was developed to provide a central nervous system with control over the output of TAH. In order to clarify the deference in hemodynamic response between natural heart and 1/R control, biventricular bypass was introduced in the goat. After 2 pneumatically driven sac-type blood pumps were connected to the natural heart, the pulmonary artery was totally clamped to acquire 100% right heart bypass, and the ascending aorta was stenosed to acquire about 60 to 90% left heart bypass; 1/R control was performed substituting the output of the right artificial heart for the CO. The results demonstrated that stable control could be achieved. A discrepancy was often seen between the pulse rate (PR) of the artificial heart and the heart rate (HR) in absolute value. However, the relative changes of PR were quite similar to that of HR for the most part, indicating that the responses of 1/R control were the duplication of natural cardiac responses in normal daily activity.
Y Abe; T Chinzei; T Isoyama; S Mochizuki; I Saito; T Karita; T Ono; A Kouno; K Baba; K Imachi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Artificial organs     Volume:  24     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-06-13     Completed Date:  2000-06-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  312-5     Citation Subset:  IM    
Department of Biomedical Engineering, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
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MeSH Terms
Aortic Valve Stenosis / physiopathology
Atrial Function, Right / physiology
Blood Pressure / physiology*
Cardiac Output / physiology*
Heart Rate / physiology*
Heart, Artificial*
Hemodynamics / physiology*
Pulmonary Artery / physiopathology
Stroke Volume / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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