| Analysis of the harmonized growth pattern of fetal organs by multidimensional scaling and hierarchical clustering. | |
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MedLine Citation:
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PMID: 20584035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The development of an organ may be affected by various growth and differentiation factors released from other organs. These factors are believed to have important effects on the development of multiple organs. To detect and analyze harmonized development among multiple organs, similarities in growth patterns among fetal organs were examined using multivariate analysis. Ninety human fetuses obtained from the Kyoto Collection of Human Embryos were dissected. Harmonized development of organs was evaluated by multidimensional scaling and cluster analysis using measurements (length, width, height, and weight) of the fetal organs. Similar growth patterns were observed between the brain, including cerebrum, diencephalon, and midbrain (cerebrum-to-midbrain [Cer-Mid]), and pituitary (crown-rump length [CRL] 95-155 mm). Further, similar growth patterns were observed between the liver and Cer-Mid and cerebellum (Cb; CRL 156-202 mm), and between Cer-Mid and Cb (CRL 203-253 mm). Similarities in growth patterns were also observed between right and left lungs (CRL 99-235 mm) and between the aorta and heart (CRL 139-187 mm), but not between the lung and pulmonary trunk. These findings revealed synchronized development among fetal organs and suggested a functional and structural relationship among different organs in the prenatal period. These relationships include the existence of common factors in organ development, such as cross-talk mediated by humoral factors, and the presence of an anatomical and functional relationship in the fetal circulatory system. |
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Authors:
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Jun Udagawa; Akira Yasuda; Kanta Naito; Hiroki Otani |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-24 |
Journal Detail:
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Title: Congenital anomalies Volume: 50 ISSN: 1741-4520 ISO Abbreviation: Congenit Anom (Kyoto) Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-24 Completed Date: 2010-12-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9306292 Medline TA: Congenit Anom (Kyoto) Country: Japan |
Other Details:
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Languages: eng Pagination: 175-85 Citation Subset: IM |
Affiliation:
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Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Japan. jun@med.shimane-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
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embryology Brain / embryology Cluster Analysis Crown-Rump Length Female Fetal Development* Fetal Growth Retardation Humans Kidney / embryology Lung / embryology Pregnancy Spleen / embryology |
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