Document Detail

Analysis of forced wheezes in asthma patients.
MedLine Citation:
PMID:  16113517     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Spirometric parameters can be normal in many stable asthma patients, making a diagnosis difficult at certain times in the course of disease. OBJECTIVES: The present study aims to find differences and similarities in the acoustic characteristics of forced wheezes among asthma patients with and without normal spirometric values. METHODS: Eleven chronic asthma patients (8 men/3 women) with moderate-to-severe airway obstruction (FEV1 48.4%), 9 stable asthma patients (6 males/3 females) with normal spirometry (FEV1 84.0%) and a positive methacholine test and 14 healthy subjects (8/6) were enrolled in the study. A contact sensor was placed on the trachea, and wheezes were detected by a modified Shabtai-Musih algorithm in a time-frequency representation. RESULTS: More wheezes were recorded in obstructive asthma patients than in stable asthma and control subjects: nonstable asthma 13.6 (13.3), stable asthma 3.5 (3.0) and control subjects 2.5 (2.1). The mean frequency of all wheezes detected was higher in control subjects than in either stable or non-stable asthma patients. The change in the total number of wheezes after terbutaline inhalation was more pronounced in nonstable asthma patients than in stable asthmatics and control subjects. CONCLUSIONS: This study confirms that wheeze recording during forced expiratory maneuvers can be a complementary measure to spirometry to identify asthma patients.
J A Fiz; R Jané; J Izquierdo; A Homs; M A García; R Gomez; E Monso; J Morera
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-08-17
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  73     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  2006  
Date Detail:
Created Date:  2006-03-01     Completed Date:  2006-06-15     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  55-60     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel.
Servicio de Neumología, Hospital Universitario Germans Trias i Pujol, Badalona, Spain.
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MeSH Terms
Asthma / physiopathology*
Chronic Disease
Middle Aged
Respiratory Function Tests
Respiratory Sounds / physiopathology*
Signal Processing, Computer-Assisted

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