| Analysis of fatty acid composition in human bone marrow aspirates. | |
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MedLine Citation:
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PMID: 16237277 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present study, the fatty acid composition of bone marrow aspirates and serum phospholipids in nine patients with hematologic diseases was investigated, and the effect of fatty acids on osteoblast differentiation in ST2 cells was examined. The concentrations of oleic acid and palmitic acid were significantly higher in bone marrow aspirates than in serum phospholipids, but the concentrations of other fatty acids did not differ. The rate of alkaline phosphatase positive ST2 cells induced by BMP2 was significantly increased by oleic acid, but was unaffected by the presence or absence of palmitic acid. We conclude that the fatty acid composition of bone marrow aspirates differs from that of serum phospholipids. This difference may affect osteoblast differentiation in the bone marrow microenvironment. |
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Authors:
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Ryota Deshimaru; Ken Ishitani; Kazuya Makita; Fumi Horiguchi; Shiro Nozawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Keio journal of medicine Volume: 54 ISSN: 0022-9717 ISO Abbreviation: Keio J Med Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-10-20 Completed Date: 2005-12-02 Revised Date: 2008-08-07 |
Medline Journal Info:
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Nlm Unique ID: 0376354 Medline TA: Keio J Med Country: Japan |
Other Details:
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Languages: eng Pagination: 150-5 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipocytes
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cytology,
drug effects Adult Aged Aged, 80 and over Animals Bone Marrow / chemistry*, pathology Cell Differentiation / drug effects Cell Line Fatty Acids / analysis*, blood Female Hematologic Diseases / blood, metabolism, pathology Humans Mice Middle Aged Oleic Acid / pharmacology Osteoblasts / cytology, drug effects Palmitic Acid / pharmacology Phospholipids / blood, chemistry |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Phospholipids; 112-80-1/Oleic Acid; 57-10-3/Palmitic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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