| Analysis of the expression of hyaluronan in intraductal and invasive carcinomas of the breast. | |
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MedLine Citation:
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PMID: 19898865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To evaluate hyaluronan expression at different stages of tumoral progression in primary breast cancer. METHODS: Hyaluronan expression was evaluated by histochemical techniques in 42 cases of pure DCIS, in 15 cases of DCIS with a microinvasive component, and in 32 cases of invasive ductal carcinoma of the breast. Staining results were evaluated by calculating the percentage of stained areas by means of a specific software program. RESULTS: Our results show higher values of hyaluronan expression in invasive breast carcinomas [median of percentage of stained areas 41.1 (range 8-69.2)] and in DCIS with a microinvasive component [48.6 (16.8-62.8)] than in pure DCIS [14.5 (1-44.4)] (p < 0.001, for both). CONCLUSIONS: Our study indicates a proportionally higher area of hyaluronan expression in DCIS with a microinvasive component than in pure DCIS, suggesting a key role of this glycosaminoglycan in the early invasive phase of breast carcinomas. Thus, hyaluronan could play an important function in determining the migratory phenotype of cancer cells. Larger size tumors appear to demonstrate an intricate balance between hyaluronan synthesis and degradation, thus conditioning intratumoral heterogeneity in the hyaluronan metabolism. |
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Authors:
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Maria Daniela Corte; Luis Ovidio Gonz?lez; Sara Junquera; Miguel Bongera; Maria Teresa Allende; Francisco Jos? Vizoso |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-07 |
Journal Detail:
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Title: Journal of cancer research and clinical oncology Volume: 136 ISSN: 1432-1335 ISO Abbreviation: J. Cancer Res. Clin. Oncol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-03-19 Completed Date: 2010-04-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902060 Medline TA: J Cancer Res Clin Oncol Country: Germany |
Other Details:
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Languages: eng Pagination: 745-50 Citation Subset: IM |
Affiliation:
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Hospital de Jove, Gij?n, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breast Neoplasms
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metabolism*,
pathology Carcinoma, Intraductal, Noninfiltrating / metabolism*, pathology Disease Progression Female Humans Hyaluronic Acid / metabolism* Middle Aged Neoplasm Invasiveness |
| Chemical | |
Reg. No./Substance:
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9004-61-9/Hyaluronic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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