Document Detail


Analysis of expression and function of the inhibitory receptor ILT2 in lymphocytes from patients with autoimmune thyroid disease.
MedLine Citation:
PMID:  21551166     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: Autoimmune thyroid disease (AITD) is characterized by different defects in immunoregulatory mechanisms. The immunoglobulin-like transcript receptor 2 (ILT2 or LIR1/CD85j) exerts an important immunoregulatory role. We hypothesized that the lymphocytes from AITD patients have a diminished expression and function of ILT2. The aim of this work was to study the expression and function of ILT2 in lymphocytes from patients with AITD. Design and methods: Eighteen patients with Hashimoto's thyroiditis (HT), twenty with Graves' disease (GD), and twenty-six healthy controls were studied. ILT2 expression was analyzed by flow cytometry and immunohistochemistry in peripheral blood mononuclear cells (PBMC), and thyroid tissue. The regulatory function of ILT2 was assessed by an assay of inhibition of lymphocyte proliferation, and by analysis of cell cycle progression. The effect of ILT2 on cytokine synthesis was also evaluated. Results: We found a significant increased expression of ILT2 by lymphocytes in AITD patients. ILT2 was also detected in the leukocyte infiltrate of thyroid tissue from HT patients. In contrast, a significant diminished inhibitory activity of ILT2 on cell proliferation was observed in AITD patients. In addition, PBMC from AITD patients showed a diminished synthesis of IL-10 upon ILT2 engagement. Conclusions: The abnormal expression and function of ILT2 detected in AITD suggests that this receptor may participate in the pathogenesis of this condition.
Authors:
Lesly Doníz-Padilla; Amalia Paniagua; Pilar Sandoval-Correa; Adriana Monsiváis-Urenda; Susanna Leskela; Monica Marazuela; Roberto González-Amaro
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-6
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  -     ISSN:  1479-683X     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
L Doníz-Padilla, Immunology, Facultad de Medicina, UASLP, SLP, Mexico.
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