Document Detail


Analysis of expression and function of the inhibitory receptor ILT2 (CD85j/LILRB1/LIR-1) in peripheral blood mononuclear cells from patients with systemic lupus erythematosus (SLE).
MedLine Citation:
PMID:  17601702     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this work was to study the expression and function of the inhibitory receptor ILT2/CD85j in peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE). We studied 23 SLE patients as well as 17 patients with rheumatoid arthritis, 10 with fibromyalgia, and 23 healthy individuals. We found a variable level of expression of ILT2 in the PBMC from both SLE patients and controls, with no significant differences among them. However, when the expression of this receptor was assessed in cell subsets, significantly lower levels were detected in CD19+ lymphocytes from SLE patients compared with healthy controls. Functional assays performed in unfractionated PBMC, showed a significant diminished inhibitory activity of ILT2 in CD4+ and CD8+ cell subsets from SLE patients compared to either rheumatoid arthritis or fibromyalgia patients, and healthy individuals. Our results show that the PBMC from some patients with SLE show a defective expression of ILT2, and that most of them exhibit a poor function of this inhibitory receptor.
Authors:
A Monsiváis-Urenda; P Niño-Moreno; C Abud-Mendoza; L Baranda; E Layseca-Espinosa; M López-Botet; R González-Amaro
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-29
Journal Detail:
Title:  Journal of autoimmunity     Volume:  29     ISSN:  0896-8411     ISO Abbreviation:  J. Autoimmun.     Publication Date:    2007 Sep-Nov
Date Detail:
Created Date:  2007-09-17     Completed Date:  2007-12-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8812164     Medline TA:  J Autoimmun     Country:  England    
Other Details:
Languages:  eng     Pagination:  97-105     Citation Subset:  IM    
Affiliation:
Departamento de Inmunología, UASLP, Ave. V. Carranza 2405, 78210 San Luis Potosí, S.L.P., Mexico.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD / immunology,  physiology*
Apoptosis
Arthritis, Rheumatoid / immunology,  metabolism
Case-Control Studies
Cell Cycle
Cells, Cultured
Female
Fibromyalgia / immunology,  metabolism
Humans
Leukocytes, Mononuclear / immunology*,  metabolism
Lupus Erythematosus, Systemic / immunology*,  metabolism
Lymphocyte Activation
Lymphocyte Subsets / cytology,  immunology*,  metabolism*
Male
Middle Aged
Receptors, Immunologic / immunology,  physiology*
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/LILRB1 protein, human; 0/Receptors, Immunologic

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