Document Detail

Analysis of excretion fraction of uric acid.
MedLine Citation:
PMID:  17065111     Owner:  NLM     Status:  MEDLINE    
Excretion fraction of uric acid (EFUA), is one of the most important hallmarks for diagnosis of familial juvenile hyperuricemic nephropathy (FJHN) and hereditary renal hypouricemia. EFUA was measured in 20 patients with FJHN. However, low excretion fraction (<6%) was found also in healthy FJHN family members and healthy controls (ref. ranges EFUA: men 6-12%, women 6-20%). Similar finding of low EFUA was reported recently. Distribution of EFUA was further studied in 2,416 healthy controls, which were selected from 6,000 samples and divided according to age. In conclusion, finding of low EFUA in family members is a risk factor for renal damage and indication for purine metabolic investigations with subsequent molecular biology analysis. As EFUA could be found also in healthy controls--it should be interpreted with care and other features of FJHN (such as hyperuricemia, progressive renal disease in family) should be taken to account.
B Stibůrková; E Pospísilová; S Kmoch; I Sebesta
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nucleosides, nucleotides & nucleic acids     Volume:  25     ISSN:  1525-7770     ISO Abbreviation:  Nucleosides Nucleotides Nucleic Acids     Publication Date:  2006  
Date Detail:
Created Date:  2006-10-26     Completed Date:  2007-01-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892832     Medline TA:  Nucleosides Nucleotides Nucleic Acids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1301-4     Citation Subset:  IM    
Institute of Inherited Metabolic Disorders, Charles University 1st School of Medicine, Prague, Czech Republic.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Case-Control Studies
Chemistry, Clinical / methods*
Child, Preschool
Hyperuricemia / diagnosis,  genetics*,  urine*
Infant, Newborn
Kidney Diseases / diagnosis,  genetics*,  urine*
Middle Aged
Reference Values
Risk Factors
Uric Acid / urine*
Urinalysis / methods
Reg. No./Substance:
69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Familial nephropathy associated with hyperuricemia in Spain: our experience with 3 families harbouri...
Next Document:  An unusual cause of renal amyloidosis secondary to gout: the first description of familial occurrenc...