| Analysis of excitatory microcircuitry in the medial entorhinal cortex reveals cell-type-specific differences. | |
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MedLine Citation:
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PMID: 21172609 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Medial entorhinal cortex (MEC) plays an important role in physiological processes underlying navigation, learning, and memory. Excitatory cells in the different MEC layers project in a region-specific manner to the hippocampus. However, the intrinsic microcircuitry of the main excitatory cells in the superficial MEC layers is largely unknown. Using scanning photostimulation, we investigated the functional microcircuitry of two such cell types, stellate and pyramidal cells. We found cell-type-specific intralaminar and ascending interlaminar feedback inputs. The ascending interlaminar inputs display distinct organizational principles depending on the cell-type and its position within the superficial lamina: the spatial spread of inputs for stellate cells is narrower than for pyramidal cells, while inputs to pyramidal cells in layer 3, but not in layer 2, exhibit an asymmetric offset to the medial side of the cell's main axis. Differential laminar sources of excitatory inputs might contribute to the functional diversity of stellate and pyramidal cells. |
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Authors:
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Prateep Beed; Michael H K Bendels; Hauke F Wiegand; Christian Leibold; Friedrich W Johenning; Dietmar Schmitz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuron Volume: 68 ISSN: 1097-4199 ISO Abbreviation: Neuron Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8809320 Medline TA: Neuron Country: United States |
Other Details:
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Languages: eng Pagination: 1059-66 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Neuroscience Research Center, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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