Document Detail

Analysis of epithelial-myoepithelial carcinoma based on the establishment of a novel cell line.
MedLine Citation:
PMID:  12747969     Owner:  NLM     Status:  MEDLINE    
Epithelial-myoepithelial carcinoma of the salivary gland is a rare, low-grade, neoplasm, composed of ductal and myoepithelial cells. We present two novel cell lines, which have been characterised by immunofluorescence, derived from an epithelial-myoepithelial carcinoma of the parotid gland. A resected mass of the parotid gland was diagnosed as an epithelial-myoepithelial carcinoma by routine histological examination. Part of the specimen was labelled with a panel of antibodies confirming the tumour type. The other part was finely minced and the explants were incubated in DMEM supplemented with penicillin and streptomycin, at 37 degrees C in a humidified 5% CO(2) atmosphere. Two cell types were identified by immunofluorescence-a small cobblestone cell, positive for AE1/AE3 and p53, and a polyhedral cell, positive for vimentin, smooth muscle markers and S-100. Herein two cell lines are presented in order to open up possibilities of new studies and a discussion of the events that culminate in this bimodal neoplasm is also performed.
A Mantesso; S V L Loducca; R G Jaeger; S P J Décio; V C Araújo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oral oncology     Volume:  39     ISSN:  1368-8375     ISO Abbreviation:  Oral Oncol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-05-15     Completed Date:  2003-06-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9709118     Medline TA:  Oral Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  453-8     Citation Subset:  IM    
Dental Research Institute, São Leopoldo Mandic-Rua Abolição 1827, Swift, SP, CEP 13045-610, Campinas, Brazil.
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MeSH Terms
Carcinoma / chemistry,  pathology*
Cell Culture Techniques / methods
Keratins / analysis
Neoplasm Proteins / analysis
Nuclear Proteins*
Parotid Neoplasms / chemistry,  pathology*
Proto-Oncogene Proteins / analysis
Proto-Oncogene Proteins c-mdm2
Tumor Cells, Cultured / chemistry,  pathology*
Tumor Suppressor Protein p53 / analysis
Reg. No./Substance:
0/Neoplasm Proteins; 0/Nuclear Proteins; 0/Proto-Oncogene Proteins; 0/Tumor Suppressor Protein p53; 68238-35-7/Keratins; EC protein, human; EC Proteins c-mdm2

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