Document Detail

Analysis of the double occlusion which provides four pressure gradients.
MedLine Citation:
PMID:  8980972     Owner:  NLM     Status:  MEDLINE    
The arterial, double and venous occlusions are used to partition pulmonary vascular resistance into four segments. In this study, we tested whether the same can be accomplished from one double occlusion. In an isolated canine lung left lower lobe perfused with blood (flow rate = 500 mL.min-1), the pulmonary arterial and venous pressures (Pa and Pv, respectively) were measured directly. Arterial, double, and venous occlusions were performed and analysed as usual (Method 1) to measure pressures in small arteries and small veins (Pa' and Pv', respectively) and capillary pressure (Pc). Alternatively, one double occlusion was analysed (Method 2), not only for Pa, Pv and Pc, but also as independent arterial and venous occlusions to measure Pa' and Pv'. Method 1 yielded Pa, Pa', Pc, Pv', and Pv (Baseline) of 14.2 +/- 1.7, 10.8 +/- 1.6, 8.9 +/- 1.9, 7.3 +/- 1.5 and 1.3 +/- 0.6 mmHg, respectively (1 mmHg = 0.133 kPa). Method 2 yielded values for the same five pressures equal to 14.7 +/- 2.1, 11.0 +/- 2.2, 8.9 +/- 1.9, 7.3 +/- 1.3 and 1.3 +/- 0.6 mmHg, respectively. There was no significant difference in the pressure profile obtained using the two methods, nor were there differences during hypoxia and angiotensin infusion. These results suggest that a more thorough analysis of the double occlusion can provide the same information about distribution of vascular resistance as provided by a combination of the three occlusions. The advantage of the new approach is that fewer occlusions are needed and resistance distribution can be assessed during a transient response. Because all pressures are derived from one occlusion, the pressures would be more accurate relative to each other.
T S Hakim; K Sugimori; L Ferrario
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  9     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-03-18     Completed Date:  1997-03-18     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  2578-83     Citation Subset:  IM    
Dept of Surgery, Health Science Center, Syracuse, New York, USA.
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MeSH Terms
Pulmonary Artery / physiology*
Pulmonary Circulation / physiology*
Pulmonary Veins / physiology*
Vascular Resistance / physiology*

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