Document Detail


Analysis of differential BRAF(V600E) mutational status in high aggressive papillary thyroid microcarcinoma.
MedLine Citation:
PMID:  19034577     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Papillary thyroid cancers often occur as microcarcinoma. Some papillary thyroid microcarcinoma (PTMC) have been considered to be high aggressive according to advanced disease stages, extrathyroidal extension, and severe cervical lymph node metastasis. Although several factors are thought to predict the occurrence of aggressiveness from PTMCs, the origin of aggressiveness has been rarely studied. To answer this question, the correlation between BRAF(V600E) mutation and high aggressive PTMCs was investigated. The clinicopathological characteristic of totally 64 cases of PTMCs was investigated and the BRAF(V600E) mutational status of them was identified. BRAF(V600E) mutation was exclusively detected in PTMCs (37.5%). The data provided no correlation between the occurrence of BRAF(V600E) mutations and clinicopathological parameters, such as sex, age, and tumor-like lesions combination. The prevalence of BRAF(V600E) mutation of PTMCs with high aggressiveness (advanced disease stages, extrathyroidal extension, and nodal metastasis) was significantly higher (p < 0.05) than that of PTMCs without aggressive behavior. The BRAF(V600E) mutated PTMCs exhibited signs of higher aggressiveness than PTMCs without the mutation. BRAF(V600E) mutation may be a marker of high aggressiveness in PTMCs.
Authors:
Xiaolong Lee; Ming Gao; Yifeng Ji; Yang Yu; Ying Feng; Yigong Li; Yan Zhang; Wenyuan Cheng; Wenchuan Zhao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-26
Journal Detail:
Title:  Annals of surgical oncology     Volume:  16     ISSN:  1534-4681     ISO Abbreviation:  Ann. Surg. Oncol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-02     Completed Date:  2009-04-30     Revised Date:  2012-06-21    
Medline Journal Info:
Nlm Unique ID:  9420840     Medline TA:  Ann Surg Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  240-5     Citation Subset:  IM    
Affiliation:
Department of Thyroid & Neck, Tianjin Medical University Cancer Hospital, Tianjin, China.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / genetics,  secondary
Carcinoma, Papillary / genetics*,  secondary
DNA Mutational Analysis
Female
Humans
Lymphatic Metastasis
Male
Middle Aged
Mutation / genetics*
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Prognosis
Proto-Oncogene Proteins B-raf / genetics*
Thyroid Neoplasms / genetics*,  pathology
Chemical
Reg. No./Substance:
EC 2.7.11.1/BRAF protein, human; EC 2.7.11.1/Proto-Oncogene Proteins B-raf
Comments/Corrections
Comment In:
Ann Surg Oncol. 2009 Apr;16(4):801-3   [PMID:  19159982 ]

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