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Analysis of dietary intake of selected metals in the NHEXAS-Maryland investigation.
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MedLine Citation:
PMID:  11266320     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As part of a large pilot investigation of multimedia exposure to several classes of environmental contaminants, the National Human Exposure Assessment Survey (NHEXAS)-Maryland study, we collected 388 semiquantitative food checklists and duplicate diet solid food samples, analyzed for arsenic, cadmium, chromium, and lead concentrations, from 80 individuals in Maryland in 1995-1996 in a repeated measures design. Here we explore several methods to infer foods most strongly associated with concentrations of these metals observed in the duplicate diet in our data set. We employed two techniques in which logarithmically transformed metal concentrations in the duplicate diet were regressed on individual food item consumption using algorithms designed to identify the foods most associated with the observed duplicate diet concentrations. We also employed an alternative strategy in which foods to be used as independent variables in regression were selected using data collected in national food consumption and residue surveys, with regression procedures proceeding with the selected foods in a similar manner. The concordance of foods selected as major predictors among these three techniques is noteworthy and is discussed. Finally, the Dietary Exposure Potential Model (DEPM) was used with the Dietary Checklist data to predict duplicate diet concentrations within our sample. A comparison between the predicted values and those observed gave R(2) values of 0.180, 0.206, and 0.076 for As, Cd, and Pb, respectively (p < 0.0001 in all cases). We discuss the significance of these observations and the implications for dietary-exposure-based risk analysis and dietary intake epidemiology.
Authors:
P B Ryan; K A Scanlon; D L MacIntosh
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Environmental health perspectives     Volume:  109     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-27     Completed Date:  2001-05-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  United States    
Other Details:
Languages:  eng     Pagination:  121-8     Citation Subset:  IM    
Affiliation:
Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA. bryan@sph.emory.edu
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MeSH Terms
Descriptor/Qualifier:
Arsenic / analysis
Cadmium / analysis
Chromium / analysis
Diet* / adverse effects
Environmental Exposure / analysis*,  statistics & numerical data
Food Analysis / methods*,  statistics & numerical data
Humans
Lead / analysis
Maryland
Metals / administration & dosage*,  analysis
Multivariate Analysis
Pilot Projects
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Metals; 7439-92-1/Lead; 7440-38-2/Arsenic; 7440-43-9/Cadmium; 7440-47-3/Chromium
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Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 2 Year: 2001
Volume: 109 Issue: 2
First Page: 121 Last Page: 128
ID: 1240630
PubMed Id: 11266320
Publisher Item Identifier: sc271_5_1835

Analysis of dietary intake of selected metals in the NHEXAS-Maryland investigation.
P B Ryan
K A Scanlon
D L MacIntosh
Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA. bryan@sph.emory.edu


Article Categories:
  • Research Article


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