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[Analysis on the depression related factors in elderly patients after stroke and the effect of Chinese medicine on them].
MedLine Citation:
PMID:  21275160     Owner:  NLM     Status:  In-Process    
OBJECTIVE: To study the depression related factors in elderly patients after stroke and to explore the effect of Chinese medicine anti-depression treatment for improving neurological function in patients with after-stroke depression.
METHODS: Three hundred and seventy-seven after-stroke elderly patients were sorted, according to their Hamilton Depression Scale-17 (HAMD17) scores, to the non-depression group (NDG, 116 patients) and the depression group (DG, 261 patients). The depression related factors in them were analysed. Moreover, patients in DG were randomly subassigned to two groups, the 135 patients in the treated group were treated with Chinese medicine and general stroke-treatment, and the 126 patients in the control group were treated only with general stroke-treatment for 4 weeks. HAMD17 scores of neurological deficit (NDS), scores of sleep dysfunction rating scale (SDRS), Hamilton anxiety rating scale (HAMA), and treatment emergent symptom scale (TESS) in them were observed before and after treatment.
RESULTS: Prevalence rate of depression in patients with cerebral hemorrhage was 79.78% (71/89), significantly higher than that in patients with cerebral infarction, 65.97% (190/288, P < 0.05). Patients of stroke with lesion occurred at cerebellum, brain stem, or cerebral hemisphere (frontal lobe) and those with moderate/severe neurological deficit were more liable to suffer from depression. The HAMD17, HAMA, SDRS, and NDS scores in the treated group after treatment were all improved more significantly than in the control group (P < 0.05). NDS score reduced in the treated group significantly from 19.1 +/- 16.3 before treatment to 31.3 +/- 14.8 after treatment, showing the evident recovery of nerve function.
CONCLUSION: The occurrence of depression after stroke is closely related with the nature and position of the lesion, as well as the degree of neurological deficit in patients. Chinese medicine could improve the depressive manner effectively and thus to make for recovery of neurological function.
Hai-Cong Li; Qiu-Bing Li; Xue-Qing Yang
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban     Volume:  30     ISSN:  1003-5370     ISO Abbreviation:  Zhongguo Zhong Xi Yi Jie He Za Zhi     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2011-01-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9211576     Medline TA:  Zhongguo Zhong Xi Yi Jie He Za Zhi     Country:  China    
Other Details:
Languages:  chi     Pagination:  1133-7     Citation Subset:  IM    
Department of Geriatrics, China-Japan Friendship Hospital, Beijing.
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