Document Detail


Analysis of cytoplasmic and surface antigens in childhood T-cell acute lymphoblastic leukaemias: clinical relevance of cytoplasmic TCR beta chain expression.
MedLine Citation:
PMID:  7947267     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Expression of surface and cytoplasmic antigens on the blasts from 42 cases of childhood T-cell acute lymphoblastic leukaemia (T-ALL) were analysed. All with childhood T-ALL, except for one case expressing cytoplasmic TCR delta chain, were classified on the basis of differential expression of cytoplasmic CD3 (cCD3), TCR beta chain (cTCR beta) and surface CD3 (sCD3) into the following three groups: group I (cCD3+, cTCR beta-, sCD3-), eight cases (19.5%); group II (cCD3+, cTCR beta +, sCD3-), 23 cases (56.1%); group III (cCD3+, cTCR beta +/-, sCD3+), 10 cases (24.4%). Each group defines the stepwise maturational stage of the CD3/TCR complex along the intrathymic T-cell differentiation. Group I had the lowest initial WBC count among the three groups (P < 0.05) and showed significantly (P < 0.05) a higher event-free survival (0.75) than those of group II (0.33). There was no significant difference in both the initial WBC count and the event-free survival between groups II and III. Thus, the absence of cTCR beta in sCD3-negative T-ALL appears to be a good prognostic factor, suggesting that this classification provides a useful tool to predict the prognosis of childhood T-ALL. This is the first report, to our knowledge, studying the relationship between the expression of cytoplasmic CD3/TCR antigens and the clinical features in T-ALL.
Authors:
T Inukai; M Saito; T Mori; K Nishino; T Abe; A Kinoshita; T Suzuki; Y Kurosawa; T Okazaki; K Sugita
Related Documents :
16439727 - Retained knife blade: an unusual cause for headache following massive alcohol intake.
7863847 - The morphologic changes of endometrial spiral arterioles in iud-induced menorrhagia.
24165357 - The association between body composition and foot structure and function: a systematic ...
19139997 - The causes of intragroup aggression in rhesus macaques.
15104617 - Successful reduction of massive postpartum haemorrhage by use of guidelines and staff e...
19630127 - The value of traditional reviews in the era of systematic reviewing.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  87     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-12-22     Completed Date:  1994-12-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  273-81     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, Yamanashi Medical University, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Antigens, CD3 / analysis
Antigens, Surface / analysis
Child
Child, Preschool
Cytoplasm / immunology*
Disease-Free Survival
Female
Humans
Immunoenzyme Techniques
Leukemia-Lymphoma, Adult T-Cell / classification,  drug therapy,  immunology*,  mortality
Male
Prognosis
Receptors, Antigen, T-Cell, alpha-beta / analysis*
Chemical
Reg. No./Substance:
0/Antigens, CD3; 0/Antigens, Surface; 0/Receptors, Antigen, T-Cell, alpha-beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Detection of peripheral blood plasma cells as a predictor of disease course in patients with smoulde...
Next Document:  PCR assessment of bone marrow status in 'isolated' extramedullary relapse of childhood B-precursor a...