Document Detail

Analysis of cytoplasmic and surface antigens in childhood T-cell acute lymphoblastic leukaemias: clinical relevance of cytoplasmic TCR beta chain expression.
MedLine Citation:
PMID:  7947267     Owner:  NLM     Status:  MEDLINE    
Expression of surface and cytoplasmic antigens on the blasts from 42 cases of childhood T-cell acute lymphoblastic leukaemia (T-ALL) were analysed. All with childhood T-ALL, except for one case expressing cytoplasmic TCR delta chain, were classified on the basis of differential expression of cytoplasmic CD3 (cCD3), TCR beta chain (cTCR beta) and surface CD3 (sCD3) into the following three groups: group I (cCD3+, cTCR beta-, sCD3-), eight cases (19.5%); group II (cCD3+, cTCR beta +, sCD3-), 23 cases (56.1%); group III (cCD3+, cTCR beta +/-, sCD3+), 10 cases (24.4%). Each group defines the stepwise maturational stage of the CD3/TCR complex along the intrathymic T-cell differentiation. Group I had the lowest initial WBC count among the three groups (P < 0.05) and showed significantly (P < 0.05) a higher event-free survival (0.75) than those of group II (0.33). There was no significant difference in both the initial WBC count and the event-free survival between groups II and III. Thus, the absence of cTCR beta in sCD3-negative T-ALL appears to be a good prognostic factor, suggesting that this classification provides a useful tool to predict the prognosis of childhood T-ALL. This is the first report, to our knowledge, studying the relationship between the expression of cytoplasmic CD3/TCR antigens and the clinical features in T-ALL.
T Inukai; M Saito; T Mori; K Nishino; T Abe; A Kinoshita; T Suzuki; Y Kurosawa; T Okazaki; K Sugita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  87     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-12-22     Completed Date:  1994-12-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  273-81     Citation Subset:  IM    
Department of Paediatrics, Yamanashi Medical University, Japan.
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MeSH Terms
Antigens, CD3 / analysis
Antigens, Surface / analysis
Child, Preschool
Cytoplasm / immunology*
Disease-Free Survival
Immunoenzyme Techniques
Leukemia-Lymphoma, Adult T-Cell / classification,  drug therapy,  immunology*,  mortality
Receptors, Antigen, T-Cell, alpha-beta / analysis*
Reg. No./Substance:
0/Antigens, CD3; 0/Antigens, Surface; 0/Receptors, Antigen, T-Cell, alpha-beta

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