| Analysis of craniofacial growth in Crouzon syndrome using landmark data. | |
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MedLine Citation:
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PMID: 2373755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Finite-element scaling analysis (FESA), generalized procrustes analysis (GPA), and Euclidean distance matrix analysis (EDMA) are applied in a two-dimensional study of craniofacial growth in normal children and those affected with Crouzon syndrome. Longitudinal data are used and growth is measured as change local to 10 craniofacial landmarks. Although details of the results vary among the methods, all 3 methods determine Crouzon growth to be different from normal. Nuances of the methods, especially the use of superimposition in GPA and lack of superimposition in 2 others are partly responsible for the varying results. Although Crouzon craniofacial morphology is often obvious at birth, this study demonstrates that there are general differences between normal postnatal growth patterns and those of the Crouzon individual. These patterns of malgrowth are in part responsible for the adult morphology of the Crouzon craniofacial complex. |
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Authors:
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J T Richtsmeier; S Lele |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of craniofacial genetics and developmental biology Volume: 10 ISSN: 0270-4145 ISO Abbreviation: J. Craniofac. Genet. Dev. Biol. Publication Date: 1990 |
Date Detail:
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Created Date: 1990-08-29 Completed Date: 1990-08-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8109845 Medline TA: J Craniofac Genet Dev Biol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 39-62 Citation Subset: IM |
Affiliation:
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Department of Cell Biology and Anatomy, School of Medicine, Johns Hopkins University, Baltimore, MD 21205. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anthropometry / methods Bone Development* Brain / growth & development Child Craniofacial Dysostosis / physiopathology* Facial Bones / growth & development* Humans Infant Longitudinal Studies Male Skull / growth & development* |
| Grant Support | |
ID/Acronym/Agency:
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SO-7-RR05378/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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