Document Detail

Analysis of craniofacial growth in Crouzon syndrome using landmark data.
MedLine Citation:
PMID:  2373755     Owner:  NLM     Status:  MEDLINE    
Finite-element scaling analysis (FESA), generalized procrustes analysis (GPA), and Euclidean distance matrix analysis (EDMA) are applied in a two-dimensional study of craniofacial growth in normal children and those affected with Crouzon syndrome. Longitudinal data are used and growth is measured as change local to 10 craniofacial landmarks. Although details of the results vary among the methods, all 3 methods determine Crouzon growth to be different from normal. Nuances of the methods, especially the use of superimposition in GPA and lack of superimposition in 2 others are partly responsible for the varying results. Although Crouzon craniofacial morphology is often obvious at birth, this study demonstrates that there are general differences between normal postnatal growth patterns and those of the Crouzon individual. These patterns of malgrowth are in part responsible for the adult morphology of the Crouzon craniofacial complex.
J T Richtsmeier; S Lele
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of craniofacial genetics and developmental biology     Volume:  10     ISSN:  0270-4145     ISO Abbreviation:  J. Craniofac. Genet. Dev. Biol.     Publication Date:  1990  
Date Detail:
Created Date:  1990-08-29     Completed Date:  1990-08-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8109845     Medline TA:  J Craniofac Genet Dev Biol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  39-62     Citation Subset:  IM    
Department of Cell Biology and Anatomy, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.
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MeSH Terms
Anthropometry / methods
Bone Development*
Brain / growth & development
Craniofacial Dysostosis / physiopathology*
Facial Bones / growth & development*
Longitudinal Studies
Skull / growth & development*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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