Document Detail

Analysis of craniofacial and extremity growth in patients with growth hormone deficiency during growth hormone therapy.
MedLine Citation:
PMID:  19188743     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: There are many controversies regarding side effects on craniofacial and extremity growth due to growth hormone (GH) treatment. Our aim was to estimate GH action on craniofacial development and extremity growth in GH-deficient patients.
METHODS: Twenty patients with GH deficiency with a chronological age ranging from 4.6 to 24.3 years (bone age from 1.5 to 13 years) were divided in 2 groups: group 1 (n = 6), naive to GH treatment, and group 2 (n = 14), ongoing GH treatment for 2-11 years. GH doses (0.1-0.15 U/kg/day) were adjusted to maintain insulin-like growth factor 1 and insulin-like growth factor binding protein 3 levels within the normal range. Anthropometric measurements, cephalometric analyses and facial photographs to verify profile and harmony were performed annually for at least 3 years.
RESULTS: Two patients with a disharmonious profile due to mandibular growth attained harmony, and none of them developed facial disharmony. Increased hand or foot size (>P97) was observed in 2 female patients and in 4 patients (1 female), respectively, both not correlated with GH treatment duration and increased levels of insulin-like growth factor 1.
CONCLUSIONS: GH treatment with standard doses in GH-deficient patients can improve the facial profile in retrognathic patients and does not lead to facial disharmony although extremity growth, mainly involving the feet, can occur.
Maria Estela Justamante de Faria; Luciani R Carvalho; Shirley M Rossetto; Terezinha Sampaio Amaral; Karina Berger; Ivo Jorge Prado Arnhold; Berenice Bilharinho Mendonca
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2009-02-03
Journal Detail:
Title:  Hormone research     Volume:  71     ISSN:  1423-0046     ISO Abbreviation:  Horm. Res.     Publication Date:  2009  
Date Detail:
Created Date:  2009-02-03     Completed Date:  2009-05-07     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  173-7     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
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MeSH Terms
Child, Preschool
Extremities / growth & development*
Face / anatomy & histology
Foot / growth & development
Growth Disorders / drug therapy*
Hand / growth & development
Human Growth Hormone / deficiency*,  therapeutic use*
Maxillofacial Development / drug effects,  physiology
Models, Biological
Skull / growth & development*
Young Adult
Reg. No./Substance:
12629-01-5/Human Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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