| Analysis of craniofacial and extremity growth in patients with growth hormone deficiency during growth hormone therapy. | |
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MedLine Citation:
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PMID: 19188743 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Background/Aims: There are many controversies regarding side effects on craniofacial and extremity growth due to growth hormone (GH) treatment. Our aim was to estimate GH action on craniofacial development and extremity growth in GH-deficient patients. Methods: Twenty patients with GH deficiency with a chronological age ranging from 4.6 to 24.3 years (bone age from 1.5 to 13 years) were divided in 2 groups: group 1 (n = 6), naive to GH treatment, and group 2 (n = 14), ongoing GH treatment for 2-11 years. GH doses (0.1-0.15 U/kg/day) were adjusted to maintain insulin-like growth factor 1 and insulin-like growth factor binding protein 3 levels within the normal range. Anthropometric measurements, cephalometric analyses and facial photographs to verify profile and harmony were performed annually for at least 3 years. Results: Two patients with a disharmonious profile due to mandibular growth attained harmony, and none of them developed facial disharmony. Increased hand or foot size (>P97) was observed in 2 female patients and in 4 patients (1 female), respectively, both not correlated with GH treatment duration and increased levels of insulin-like growth factor 1. Conclusions: GH treatment with standard doses in GH-deficient patients can improve the facial profile in retrognathic patients and does not lead to facial disharmony although extremity growth, mainly involving the feet, can occur. |
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Authors:
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Maria Estela Justamante de Faria; Luciani R Carvalho; Shirley M Rossetto; Terezinha Sampaio Amaral; Karina Berger; Ivo Jorge Prado Arnhold; Berenice Bilharinho Mendonca |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2009-02-03 |
Journal Detail:
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Title: Hormone research Volume: 71 ISSN: 1423-0046 ISO Abbreviation: Horm. Res. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-02-03 Completed Date: 2009-05-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0366126 Medline TA: Horm Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 173-7 Citation Subset: IM |
Copyright Information:
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Copyright 2009 S. Karger AG, Basel. |
Affiliation:
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Divisão de Odontologia do Instituto Central, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil. mejfaria@uol.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cephalometry Child Child, Preschool Extremities / growth & development* Face / anatomy & histology Female Foot / growth & development Growth Disorders / drug therapy* Hand / growth & development Human Growth Hormone / deficiency*, therapeutic use* Humans Male Maxillofacial Development / drug effects, physiology Models, Biological Skull / growth & development* Young Adult |
| Chemical | |
Reg. No./Substance:
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12629-01-5/Human Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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