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Analysis of coronary bifurcations by intravascular ultrasound and virtual histology.
MedLine Citation:
PMID:  20667407     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Regional differences in shear stress have been identified as reason for early plaque formation in vessel bifurcations. We aimed to investigate regional plaque morphology and composition using intravascular ultrasound (IVUS) and virtual histology (IVUS-VH) in coronary artery bifurcations.
METHODS: We performed IVUS and IVUS-VH studies at coronary bifurcations to analyze segmental plaque burden and composition of different segments in relation to their orientation to the bifurcation.
RESULTS: A total of 236 patients with a mean age of 59±11 years (69% male) were analyzed. Plaque burden was higher at the contralateral vessel wall facing the bifurcation compared to the ipsilateral vessel wall and this difference was true for proximal and distal segments (proximal: 37±12% and 45±15% for segments at the ipsilateral and contralateral vessel wall, respectively, p<0.001; distal: 37±10% and 47±15% for segments at the ipsilateral and contralateral vessel wall, respectively, p<0.001). In addition, these segments exhibited a higher proportion of dense calcium and a lower proportion of fibrous tissue and fibro fatty tissue.
CONCLUSIONS: Segments on the contralateral wall of the bifurcation which have previously been identified as regions with low shear stress not only exhibited a higher plaque burden, but also a higher degree of calcification.
Authors:
Stefan Toggweiler; Nadja Urbanek; Andreas W Schoenenberger; Paul Erne
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-07
Journal Detail:
Title:  Atherosclerosis     Volume:  212     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  524-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Cardiology, Luzerner Kantonsspital, CH-6000 Luzern 16, Switzerland.
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