| Analysis of the core region of HCV genome isolated from patients with chronic hepatitis C during intervals of normal ALT concentration. | |
| | |
MedLine Citation:
|
PMID: 8808445 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We determined the core region nucleotide and amino acid sequences in specimens from two patients with chronic hepatitis C during intervals of normal and elevated alanine aminotransferase (ALT) concentrations. When the ALT concentrations remained normal, the serum HCR-RNA concentration exceeded that before therapy and most of the clones that could be sequenced had a deletion or an amber mutation. The clones isolated from a HLA B44-positive patient had a mutation at amino acid 91. These results suggest that expression of the wild-type HCV core region genome may be associated with liver cell damage. |
| | |
Authors:
|
K Arataki; T Nakanishi; T Ohbatake; E Sanada; J Nakayama; K Katayama; F Sasaki; T Moriya; G Kajiyama |
Related Documents
:
|
15257005 - Congenital alacrima in pierre robin sequence. 10790215 - Identification of seven novel snps (five nucleotide and two amino acid substitutions) i... 8016145 - All-1 partial duplication in acute leukemia. 1431505 - Detection of properdin mrna in human peripheral blood monocytes and spleen. 3840195 - Thymus-leukemia (tl) antigens of the mouse. analysis of tl mrna and tl cdna tl+ and tl-... 3816795 - The complete amino acid sequence of rubredoxin from the green phototrophic bacterium ch... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Journal of gastroenterology Volume: 31 ISSN: 0944-1174 ISO Abbreviation: J. Gastroenterol. Publication Date: 1996 Feb |
Date Detail:
|
Created Date: 1996-11-26 Completed Date: 1996-11-26 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9430794 Medline TA: J Gastroenterol Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 140-2 Citation Subset: IM |
Affiliation:
|
First Department of Internal Medicine, Hiroshima University School of Medicine, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Alanine Transaminase / blood Antiviral Agents / therapeutic use Female Genome, Viral* Hepacivirus / genetics*, isolation & purification Hepatitis C / blood, drug therapy, physiopathology* Hepatitis C Antibodies / analysis Hepatitis, Chronic / blood, drug therapy, physiopathology* Humans Interferons / therapeutic use Male Middle Aged Polymerase Chain Reaction RNA, Viral / analysis |
| Chemical | |
Reg. No./Substance:
|
0/Antiviral Agents; 0/Hepatitis C Antibodies; 0/RNA, Viral; 9008-11-1/Interferons; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Overexpression of bone morphogenic protein (BMP)-4 mRNA in gastric cancer cell lines of poorly diffe...
Next Document: Erythropoietin can be administered during dialysis. A kinetic analysis.