Document Detail

Analysis of the core region of HCV genome isolated from patients with chronic hepatitis C during intervals of normal ALT concentration.
MedLine Citation:
PMID:  8808445     Owner:  NLM     Status:  MEDLINE    
We determined the core region nucleotide and amino acid sequences in specimens from two patients with chronic hepatitis C during intervals of normal and elevated alanine aminotransferase (ALT) concentrations. When the ALT concentrations remained normal, the serum HCR-RNA concentration exceeded that before therapy and most of the clones that could be sequenced had a deletion or an amber mutation. The clones isolated from a HLA B44-positive patient had a mutation at amino acid 91. These results suggest that expression of the wild-type HCV core region genome may be associated with liver cell damage.
K Arataki; T Nakanishi; T Ohbatake; E Sanada; J Nakayama; K Katayama; F Sasaki; T Moriya; G Kajiyama
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of gastroenterology     Volume:  31     ISSN:  0944-1174     ISO Abbreviation:  J. Gastroenterol.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-11-26     Completed Date:  1996-11-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9430794     Medline TA:  J Gastroenterol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  140-2     Citation Subset:  IM    
First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
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MeSH Terms
Alanine Transaminase / blood
Antiviral Agents / therapeutic use
Genome, Viral*
Hepacivirus / genetics*,  isolation & purification
Hepatitis C / blood,  drug therapy,  physiopathology*
Hepatitis C Antibodies / analysis
Hepatitis, Chronic / blood,  drug therapy,  physiopathology*
Interferons / therapeutic use
Middle Aged
Polymerase Chain Reaction
RNA, Viral / analysis
Reg. No./Substance:
0/Antiviral Agents; 0/Hepatitis C Antibodies; 0/RNA, Viral; 9008-11-1/Interferons; EC Transaminase

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