Document Detail

Analysis of the core region of HCV genome isolated from patients with chronic hepatitis C during intervals of normal ALT concentration.
MedLine Citation:
PMID:  8808445     Owner:  NLM     Status:  MEDLINE    
We determined the core region nucleotide and amino acid sequences in specimens from two patients with chronic hepatitis C during intervals of normal and elevated alanine aminotransferase (ALT) concentrations. When the ALT concentrations remained normal, the serum HCR-RNA concentration exceeded that before therapy and most of the clones that could be sequenced had a deletion or an amber mutation. The clones isolated from a HLA B44-positive patient had a mutation at amino acid 91. These results suggest that expression of the wild-type HCV core region genome may be associated with liver cell damage.
K Arataki; T Nakanishi; T Ohbatake; E Sanada; J Nakayama; K Katayama; F Sasaki; T Moriya; G Kajiyama
Related Documents :
3139545 - Restriction endonuclease mapping of six novel deletions of the factor viii gene in hemo...
23267105 - Population genomic and genome-wide association studies of agroclimatic traits in sorghum.
7581395 - Aberrant splicing of the type iii procollagen mrna leads to intracellular degradation o...
8766525 - Biochemical characterization of alpha-fetoprotein and other serum proteins produced by ...
2796735 - Characterization of the vira virulence gene of the nopaline plasmid, ptic58, of agrobac...
2400605 - Molecular cloning of mouse acetylcholinesterase: tissue distribution of alternatively s...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of gastroenterology     Volume:  31     ISSN:  0944-1174     ISO Abbreviation:  J. Gastroenterol.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-11-26     Completed Date:  1996-11-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9430794     Medline TA:  J Gastroenterol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  140-2     Citation Subset:  IM    
First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Alanine Transaminase / blood
Antiviral Agents / therapeutic use
Genome, Viral*
Hepacivirus / genetics*,  isolation & purification
Hepatitis C / blood,  drug therapy,  physiopathology*
Hepatitis C Antibodies / analysis
Hepatitis, Chronic / blood,  drug therapy,  physiopathology*
Interferons / therapeutic use
Middle Aged
Polymerase Chain Reaction
RNA, Viral / analysis
Reg. No./Substance:
0/Antiviral Agents; 0/Hepatitis C Antibodies; 0/RNA, Viral; 9008-11-1/Interferons; EC Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Overexpression of bone morphogenic protein (BMP)-4 mRNA in gastric cancer cell lines of poorly diffe...
Next Document:  Erythropoietin can be administered during dialysis. A kinetic analysis.