| Analysis and clinical relevance of microparticles from red blood cells. | |
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MedLine Citation:
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PMID: 20960973 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: The mechanisms involved in the formation of red blood cell (RBC) microparticles in vivo as well as during erythrocyte storage are reviewed, and the potential role of microparticles in transfusion medicine is described. RECENT FINDINGS: Microparticles release is an integral part of the erythrocyte ageing process, preventing early removal of RBCs. Proteomics analyses have outlined the key role of band 3-ankyrin anchoring complex and the occurrence of selective RBC membrane remodelling mechanisms in microparticles formation. The presence of several RBC antigens, expressed on microparticles, has been demonstrated. The potential deleterious effects of RBC microparticles in transfused recipients, including hypercoagulability, microcirculation impairment and immunosuppression, are discussed. SUMMARY: Formation and role of RBC microparticles are far from being completely understood. Combining various approaches to elucidate these mechanisms could improve blood product quality and transfusion safety. Implementation of RBC microparticles as biomarkers in the laboratory routine needs to overcome technical barriers involved in their analysis. |
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Authors:
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Jean-Daniel Tissot; Olivier Rubin; Giorgia Canellini |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Current opinion in hematology Volume: 17 ISSN: 1531-7048 ISO Abbreviation: Curr. Opin. Hematol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9430802 Medline TA: Curr Opin Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 571-7 Citation Subset: IM |
Affiliation:
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Service Régional Vaudois de Transfusion Sanguine, Lausanne, Switzerland. Jean-Daniel.Tissot@mavietonsang.ch |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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