| Analysis of chemical warfare agents III. Use of bis-nucleophiles in the trace level determination of phosgene and perfluoroisobutylene. | |
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MedLine Citation:
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PMID: 16314173 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The reactivity of phosgene and perfluoroisobutylene (PFIB) towards 1,2-bis-nucleophiles was exploited to allow determination of these gases in air samples. 2-Aminothiophenol (ATP), 3,4-dimercaptotoluene (DMT) and 2-hydroxymethylpiperidine (HMP) were evaluated as bis-nucleophiles capable of forming thermally-stable derivatives with phosgene and PFIB when loaded with triethylamine onto Tenax TA. Experimental design was used to optimise thermal desorption conditions. Detection limits in the low ngm(-3) range were observed for the five derivatives investigated. This work represents the most sensitive analytical method for trace level quantitation of phosgene and PFIB published to date. |
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Authors:
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Bob Muir; David B Cooper; Wendy A Carrick; Christopher M Timperley; Ben J Slater; Suzanne Quick |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-10-05 |
Journal Detail:
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Title: Journal of chromatography. A Volume: 1098 ISSN: 0021-9673 ISO Abbreviation: J Chromatogr A Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-11-29 Completed Date: 2006-02-22 Revised Date: 2009-01-15 |
Medline Journal Info:
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Nlm Unique ID: 9318488 Medline TA: J Chromatogr A Country: Netherlands |
Other Details:
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Languages: eng Pagination: 156-65 Citation Subset: IM |
Affiliation:
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Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK. bmuir@dstl.gov.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Air
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analysis* Aniline Compounds / analysis Chemical Warfare Agents / analysis*, chemistry Ethylamines / chemistry Fluorocarbons / analysis* Gas Chromatography-Mass Spectrometry Inhalation Exposure Phosgene / analysis* Piperidines / analysis Sensitivity and Specificity Sulfhydryl Compounds / analysis Toluene / analogs & derivatives, analysis |
| Chemical | |
Reg. No./Substance:
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0/3,4-dimercaptotoluene; 0/Aniline Compounds; 0/Chemical Warfare Agents; 0/Ethylamines; 0/Fluorocarbons; 0/Piperidines; 0/Sulfhydryl Compounds; 108-88-3/Toluene; 121-44-8/triethylamine; 137-07-5/2-aminothiophenol; 382-21-8/perfluoroisobutylene; 75-44-5/Phosgene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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