Document Detail

Analysis of cellular expression of gangliosides by gene transfection. I: GD3 expression in myc-transfected and transformed 3Y1 correlates with anchorage-independent growth activity.
MedLine Citation:
PMID:  3342047     Owner:  NLM     Status:  MEDLINE    
Transfection of c-myc DNA into rat fibroblastic 3Y1 cell line resulted in the neosynthesis of GD3 ganglioside, as has been previously shown to occur after transfection of 3Y1 cells with adeno El (Nakakuma, H., Sanai, Y., Shiroki, K., and Nagai, Y. (1984) J. Biochem. 96, 1471-1480); in both cases, the products are expressed intranuclearly. Moreover, a clear correlation was identified between levels of GD3 expression and colony-forming activity (in soft agar) of myc-transformed 3Y1 cells, implying that GD3 plays some specific role in myc-induced transformation of 3Y1 cell line.
H Nakaishi; Y Sanai; K Shiroki; Y Nagai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  150     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-03-09     Completed Date:  1988-03-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  760-5     Citation Subset:  IM    
Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan.
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MeSH Terms
Cell Division
Cell Line
Cell Transformation, Neoplastic*
Embryo, Mammalian
Gangliosides / genetics*,  isolation & purification
Reg. No./Substance:
0/Gangliosides; 62010-37-1/ganglioside, GD3

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