Document Detail


Analysis of cellular expression of gangliosides by gene transfection. I: GD3 expression in myc-transfected and transformed 3Y1 correlates with anchorage-independent growth activity.
MedLine Citation:
PMID:  3342047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transfection of c-myc DNA into rat fibroblastic 3Y1 cell line resulted in the neosynthesis of GD3 ganglioside, as has been previously shown to occur after transfection of 3Y1 cells with adeno El (Nakakuma, H., Sanai, Y., Shiroki, K., and Nagai, Y. (1984) J. Biochem. 96, 1471-1480); in both cases, the products are expressed intranuclearly. Moreover, a clear correlation was identified between levels of GD3 expression and colony-forming activity (in soft agar) of myc-transformed 3Y1 cells, implying that GD3 plays some specific role in myc-induced transformation of 3Y1 cell line.
Authors:
H Nakaishi; Y Sanai; K Shiroki; Y Nagai
Related Documents :
8860837 - Gene therapy for amyotrophic lateral sclerosis (als) using a polymer encapsulated xenog...
10580697 - The dlp1 mutant of the yeast saccharomyces cerevisiae with an increased copy number of ...
16570347 - Efficient expression of histidine-tagged large hepatitis delta antigen in baculovirus-t...
21903177 - Biotransformation enzyme-dependent formation of micronucleus and multinuclei in cell li...
8800197 - Effects of ionizing- and uv b-radiation on proteins controlling cell cycle progression ...
10641717 - Damage to the cytoplasmic membrane of escherichia coli by catechin-copper (ii) complexes.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  150     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-03-09     Completed Date:  1988-03-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  760-5     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Division
Cell Line
Cell Transformation, Neoplastic*
Embryo, Mammalian
Gangliosides / genetics*,  isolation & purification
Oncogenes*
Rats
Transfection*
Chemical
Reg. No./Substance:
0/Gangliosides; 62010-37-1/ganglioside, GD3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cytochalasin E enhances the protein kinase C-dependent process of secretion.
Next Document:  Analysis of cellular expression of gangliosides by gene transfection. II: Rat 3Y1 cells transformed ...