Document Detail

Analysis of catecholamine and vasoactive peptide release in intracranial arterial venous malformations.
MedLine Citation:
PMID:  8829555     Owner:  NLM     Status:  MEDLINE    
Craniotomy for resection of cerebral arterial venous malformation has been associated with postoperative hypertension, which necessitates administration of large doses of antihypertensive medications to control blood pressure. Controlling blood pressure is essential because hypertensive episodes can lead to postoperative cerebral hemorrhage with increases in morbidity and mortality. We measured vasoactive peptide and catecholamine release in 13 patients who underwent resection of an arterial venous malformation and in a control group of 6 patients who presented for clipping of unruptured cerebral aneurysms. Plasma renin activity, angiotensin I and II, vasopressin, aldosterone, epinephrine, and norepinephrine levels were measured intraoperatively and for 36 h postoperatively. Analysis of variance was used to assess sample and group effects. A significant interaction between sample and groups was found for norepinephrine (p < 0.001) and renin (p = 0.002). Our data suggest that elevated plasma renin and norepinephrine levels are in part responsible for postoperative hypertension in patients undergoing resection of arterial venous malformations. Blocking the release of these hormones may help control blood pressure after surgery for removal of arterial venous malformations.
E L Bloomfield; D T Porembka; Z Y Ebrahim; M Grimes-Rice; M Secic; J R Little; J D Lockrem
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of neurosurgical anesthesiology     Volume:  8     ISSN:  0898-4921     ISO Abbreviation:  J Neurosurg Anesthesiol     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-10-17     Completed Date:  1996-10-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8910749     Medline TA:  J Neurosurg Anesthesiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  101-10     Citation Subset:  IM    
Department of General Anesthesiology, Cleveland Clinic Foundation, OH 44195, USA.
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MeSH Terms
Aldosterone / blood
Angiotensins / blood
Catecholamines / blood,  metabolism*
Epinephrine / blood
Intracranial Aneurysm / metabolism
Intracranial Arteriovenous Malformations / metabolism*
Intraoperative Period
Vasoactive Intestinal Peptide / blood,  metabolism*
Vasopressins / blood
Reg. No./Substance:
0/Angiotensins; 0/Catecholamines; 11000-17-2/Vasopressins; 37221-79-7/Vasoactive Intestinal Peptide; 51-43-4/Epinephrine; 52-39-1/Aldosterone

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