Document Detail

Analysis of blood spot 17 alpha-hydroxyprogesterone concentration in premature infants--proposal for cut-off limits in screening for congenital adrenal hyperplasia.
MedLine Citation:
PMID:  1621517     Owner:  NLM     Status:  MEDLINE    
Blood Spot 17 alpha-hydroxyprogesterone (17-OHP) concentrations in neonates, especially in premature babies, were determined in relation to 1) the gestational age at birth, 2) the equivalent age of gestation at blood sampling and 3) the birth weight. The 17-OHP concentrations were found to be higher with prematurity. Accordingly, the cut-off limit in screening for congenital adrenal hyperplasia (CAH) in premature infants is proposed as 20 ng/ml. Ideal cut-off limits were set by the equivalent age of gestation at blood sampling. Cut-off limits on the basis of gestational age at birth and birth weight are also suggested, where the sampling age is not so advanced. The rate of false positivity in premature infants can be reduced by this method.
S Ohkubo; K Shimozawa; M Matsumoto; T Kitagawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica Japonica; Overseas edition     Volume:  34     ISSN:  0374-5600     ISO Abbreviation:  Acta Paediatr Jpn     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-08-06     Completed Date:  1992-08-06     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370357     Medline TA:  Acta Paediatr Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  126-33     Citation Subset:  IM    
Division of Pediatrics, Tokyo Teishin Hospital, Japan.
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MeSH Terms
Adrenal Hyperplasia, Congenital / blood,  diagnosis*,  epidemiology
Blood Chemical Analysis
Hydroxyprogesterones / blood*,  immunology,  metabolism
Infant, Newborn
Infant, Premature / physiology*
Japan / epidemiology
Neonatal Screening
Predictive Value of Tests
Reg. No./Substance:

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