| Analysis of blood flow in an out-of-plane CABG model. | |
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MedLine Citation:
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PMID: 16489100 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coronary artery bypass graft (CABG) is a routine surgical treatment for ischemic and infarcted myocardium. A large number of CABG fail postoperatively because of intimal hyperplasia within months or years. The cause of this failure is thought to be partly related to the flow patterns and shear stresses acting on the endothelial cells. An accurate representation of the flow field and associated wall shear stress (WSS) requires a detailed three-dimensional (3D) model of the CABG. The purpose of this study is to present a detailed analysis of blood flow in a 3D aorto/left CABG, bypassing the occluded left anterior descending coronary (LAD) artery. The analysis takes into account the influence of the out-of-plane geometry of the graft. The finite volume technique was employed to model the 3D blood flow pattern to determine the velocity and WSS distributions. This study presents the flow field distributions of the velocity and WSS at four instances of the cardiac cycle, two in systole and two in diastole. Our results reveal that the CABG geometry has a significant effect on the velocity distribution. The axial velocity profiles at different instances of the cardiac cycle exhibit strong skewing; significant secondary flow and vortex structures are seen in the in-plane velocity patterns. The maximum WSS on the bed of the occluded LAD artery opposite to the graft junction is 14 Pa in middiastole, whereas there is a significantly lower and more uniform distribution of WSS on the bed of the anastomosis. The present results indicate that nonplanarity of the blood vessel along with the inflow conditions has a substantial effect on the fluid mechanics of CABG that contribute to the patency of graft. |
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Authors:
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Meena Sankaranarayanan; Dhanjoo N Ghista; Chua Leok Poh; Tan Yong Seng; Ghassan S Kassab |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-02-17 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 291 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-14 Completed Date: 2006-08-01 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H283-95 Citation Subset: IM |
Affiliation:
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School of Mechanical and Aerospace Engineering, National Heart Centre, Singapore. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteriosclerosis / physiopathology, surgery Blood Flow Velocity* Computer Simulation Coronary Artery Bypass / adverse effects*, methods* Coronary Vessels / physiopathology*, surgery* Graft Occlusion, Vascular / etiology*, physiopathology* Humans Models, Cardiovascular |
| Grant Support | |
ID/Acronym/Agency:
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HL-055554-06/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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