Document Detail

Analysis of the bleeding pattern in assisted reproduction cycles with luteal phase supplementation using vaginal micronized progesterone.
MedLine Citation:
PMID:  10875847     Owner:  NLM     Status:  MEDLINE    
This study was designed to determine the effects of a vaginal micronized progesterone preparation on bleeding patterns and pregnancy outcomes after in-vitro fertilization and intracytoplasmic sperm injection (IVF-ICSI). The study population consisted of 149 consecutive women who had undergone IVF-ICSI using 'long-protocol' stimulation with buserelin-human menopausal gonadotrophin (HMG). A retrospective chart analysis of computerized medical records was undertaken. Vaginal progesterone (200 mg three times daily) was begun the day before oocyte retrieval and continued for a minimum of 16-19 days following human chorionic gonadotrophin (HCG) administration. Occurrence of bleeding following HCG injection, pregnancy rate and outcomes, and serum concentrations of oestradiol were measured. Women undergoing IVF and embryo transfer with ICSI and using vaginal progesterone for luteal support had normal luteal phase lengths (day of HCG minus day of onset of bleeding). In the absence of pregnancy, bleeding occurred after 19.2 +/- 3.9 days (mean +/- SD). Out of the pregnant group only three women bled within 19 days of HCG administration: two had biochemical pregnancies which spontaneously vanished and one evolved to term. The results reflect the normal bleeding pattern to be expected when vaginal progesterone is used for luteal support in IVF and embryo transfer, an approach whose efficacy has been amply proven. No shortened luteal phases were observed using vaginally administered progesterone.
E Romàn; A Aytoz; J E Smitz; B Faguer; M Camus; A C Van Steirteghem; P Devroey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  15     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-09-08     Completed Date:  2000-09-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1435-9     Citation Subset:  IM    
Center for Reproductive Medicine, Academisch Ziekenhuis, Vrije Universiteit, Laarbeeklaan 101, 1090 Brussels, Belgium.
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MeSH Terms
Embryo Transfer
Estradiol / blood
Fertilization in Vitro*
Luteal Phase / drug effects*
Menstruation / physiology*
Middle Aged
Osmolar Concentration
Pregnancy Outcome
Progesterone / administration & dosage*,  therapeutic use
Retrospective Studies
Sperm Injections, Intracytoplasmic*
Reg. No./Substance:
0/Powders; 50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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