| Analysis of the benefits of vitamin cocktails in treating Charcot-Marie-Tooth disease type 1A. | |
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MedLine Citation:
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PMID: 18663735 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We recently proposed that the use of high doses of ascorbic acid (AA) could constitute the first potential treatment for Charcot-Marie-Tooth disease type 1A (CMT1A).4 We investigated the potential benefits of using cocktails of vitamins for CMT1A therapy. We used transient transfection of Schwann cells with a construction placing the expression of a reporter gene under the control of the Schwann cell-specific promoter of PMP22. Transfected cells were cultured with or without addition of ascorbic acid, vitamin A, vitamin E, or a cocktail of these vitamins. Adding vitamin A or E counteracts the effect of ascorbic acid in inhibiting PMP22 expression. We thus recommend that vitamins A and E should not be included in combination with AA in clinical trials. |
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Authors:
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Ferdinand Kaya; Sophie Belin; Joelle Micallef; Olivier Blin; Michel Fontés |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Muscle & nerve Volume: 38 ISSN: 0148-639X ISO Abbreviation: Muscle Nerve Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-04 Completed Date: 2008-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: United States |
Other Details:
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Languages: eng Pagination: 1052-4 Citation Subset: IM |
Affiliation:
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INSERM UMR491, TMG, IPHM-IFR125, Faculté de Médecine, 27 bd Jean Moulin, 13385 Marseille Cedex 5, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line, Transformed Drug Combinations Gene Expression Regulation / drug effects Humans Mice Myelin Proteins / genetics, metabolism* Schwann Cells / drug effects, metabolism Transfection Vitamins / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 0/Myelin Proteins; 0/PMP22 protein, human; 0/Vitamins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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