Document Detail


Analysis of background EEG activity in patients with juvenile myoclonic epilepsy.
MedLine Citation:
PMID:  18282771     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To analyze background EEG activity of patients with juvenile myoclonic epilepsy (JME) with and without antiepileptic drugs. METHODS: We studied the background EEG activity in 18 patients with JME. The qEEG analysis included absolute power (AP), relative power (RP) and mean frequency (MF) of delta, theta, alpha and beta bands. The Z scores were calculated by comparison with population parameters based on the age-dependent regression function. Seven patients were unmedicated (UM) and eleven medicated (M). RESULTS: The UM group presented 69 (4.32%) abnormal Z scores and 227 (9.05%) in the M group (P<0.001). In the UM group, AP delta abnormal Z scores were identified in frontotemporal and occipital leads. In AP alpha and beta bands an increase in Z scores was encountered in frontoparietal leads in three patients. In addition, in three patients, the AP theta Z scores were below -1.96 and distributed in all regions. In the M group, AP beta Z scores were above 1.96 in frontoparietal leads in 7 of 11 patients. The AP delta increased above 1.96 in frontotemporal and occipital leads in 6 patients of 11. The AP alpha showed an abnormal decrease in Z scores in 5 of 11 patients, whereas other 5 patients presented normal scores. The AP theta presented 7 normal Z scores out of 11; this band exhibited the lowest number of abnormalities of the 4. CONCLUSION: Patients with JME have an increase in AP delta, alpha and beta bands, which is more evident in frontoparietal regions.
Authors:
Efraín Santiago-Rodríguez; Thalía Harmony; Lizbeth Cárdenas-Morales; Adriana Hernández; Antonio Fernández-Bouzas
Publication Detail:
Type:  Journal Article     Date:  2008-02-20
Journal Detail:
Title:  Seizure : the journal of the British Epilepsy Association     Volume:  17     ISSN:  1059-1311     ISO Abbreviation:  Seizure     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-16     Completed Date:  2008-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306979     Medline TA:  Seizure     Country:  England    
Other Details:
Languages:  eng     Pagination:  437-45     Citation Subset:  IM    
Affiliation:
Unidad de Investigación en Neurodesarrollo Dr. Augusto Fernández Guardiola, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico. santiago@inb.unam.mx
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Brain / physiopathology*
Electroencephalography* / classification,  methods
Female
Humans
Male
Myoclonic Epilepsy, Juvenile / pathology,  physiopathology*
Spectrum Analysis

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