| Analysis of aphidicolin-induced chromosome fragility in the domestic pig (Sus scrofa). | |
| | |
MedLine Citation:
|
PMID: 8428508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Aphidicolin (APC)-sensitive fragile sites were identified in chromosome preparations from peripheral lymphocyte cultures of 12 four-way crossbred pigs. A chi 2 analysis demonstrated that aphidicolin-induced breakage events and previously reported in vivo chromosome rearrangement events were not independent. Comparison of expected Poisson and negative binomial distributions to observed breakage patterns indicated that the negative binomial distribution provided a better fit to experimental data. The negative binomial distribution is consistent with a distribution of breakage rates, i.e., non-constant rates of breakage at chromosomal loci across the genome. |
| | |
Authors:
|
P K Riggs; T Kuczek; C L Chrisman; C A Bidwell |
Related Documents
:
|
12393398 - A novel diagnostic screen for defects in the fanconi anemia pathway. 21789598 - The neurobiology of mouse models syntenic to human chromosome 15q. 7203468 - A case of pure red cell aplasia with a high incidence of spontaneous chromosome breakag... 2139228 - Ankyrin and the hemolytic anemia mutation, nb, map to mouse chromosome 8: presence of t... 12687498 - Mutations in mtmr13, a new pseudophosphatase homologue of mtmr2 and sbf1, in two famili... 5055128 - The t6 translocation in the mouse: its use in trisomy mapping, centromere localization,... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Cytogenetics and cell genetics Volume: 62 ISSN: 0301-0171 ISO Abbreviation: Cytogenet. Cell Genet. Publication Date: 1993 |
Date Detail:
|
Created Date: 1993-03-08 Completed Date: 1993-03-08 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0367735 Medline TA: Cytogenet Cell Genet Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 110-6 Citation Subset: IM |
Affiliation:
|
Department of Animal Sciences, Purdue University, West Lafayette, IN 47007. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aphidicolin / toxicity* Binomial Distribution Chi-Square Distribution Chromosome Aberrations Chromosome Banding Chromosome Fragile Sites Chromosome Fragility* Dose-Response Relationship, Drug Female Lymphocytes / drug effects Male Mutagens / toxicity* Poisson Distribution Swine / genetics* Translocation, Genetic* |
| Chemical | |
Reg. No./Substance:
|
0/Mutagens; 38966-21-1/Aphidicolin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Opportunistic pneumonia.
Next Document: A balanced autosomal reciprocal translocation in an azoospermic bull.