Document Detail

Analysis of antithyroid drug residues in food animals.
MedLine Citation:
PMID:  22946922     Owner:  NLM     Status:  In-Data-Review    
In the late 1970s, concerns were raised regarding why antithyroid drugs were being administered to food animals to promote growth despite the fact that they had been implicated as being carcinogenic and teratogenic; the growth promotion process produced an inferior quality meat with increased water retention in the animal's gastrointestinal tract. An increased incidence of aplasia cutis (a characteristic scalp defect) in consumers in Spain was linked to an increased consumption of antithyroid-contaminated meat. Therefore, to protect human health, the EU banned the use of antithyroid drugs in food animal production in 1981. This article reviews the impact of this regulatory decision on the regulatory analysis of these compounds in foods of animal origin. It discusses the physiology of the thyroid gland, the chemistry of antithyroid drugs and critically evaluates the suitability of the analytical methods that have been developed and validated to support enforcement of the regulation.
Joe Boison
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bioanalysis     Volume:  4     ISSN:  1757-6199     ISO Abbreviation:  Bioanalysis     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-09-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101512484     Medline TA:  Bioanalysis     Country:  England    
Other Details:
Languages:  eng     Pagination:  2067-83     Citation Subset:  IM    
Centre for Veterinary Drug Residues (CVDR), Canadian Food Inspection Agency (CFIA), 116 Veterinary Road, Saskatoon, SK, Canada, S7N 2R3.
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