| Analysis of angiotensin II mediated COX-2 downregulation in angiotensin II- or aldosterone-infused hypertensive rat. | |
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MedLine Citation:
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PMID: 12913255 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The renin-angiotensin cascade plays an important role in blood pressure control and sodium homeostasis. This study investigated whether cyclooxygenase-2 expression is regulated in the kidney, in an angiotensin II- and aldosterone-induced hypertension model. For this purpose, we treated male Sprague-Dawley rats (n=8 per group) with angiotensin II (9 mg/h, subcutaneously) for 14 d and aldosterone (0.75 mg/h, subcutaneously) for 42 d. Systolic blood pressure was significantly increased by angiotensin II (p<0.001) and by aldosterone (p<0.001). We found that angiotensin II downregulated cyclooxygenase-2 protein in the kidney cortex, whereas aldosterone showed no effect. These results indicate that angiotensin II may act directly to inhibit kidney cortex cyclooxygenase-2 protein expression, rather than acting via stimulation of aldosterone. |
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Authors:
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Won Chung Lim; Jeong Bae Park; Young Joo Lee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biological & pharmaceutical bulletin Volume: 26 ISSN: 0918-6158 ISO Abbreviation: Biol. Pharm. Bull. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-08-12 Completed Date: 2004-04-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9311984 Medline TA: Biol Pharm Bull Country: Japan |
Other Details:
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Languages: eng Pagination: 1086-8 Citation Subset: IM |
Affiliation:
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College of Bioscience, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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pharmacology* Angiotensin II / pharmacology* Animals Blood Pressure / drug effects, physiology Cyclooxygenase 2 Down-Regulation / drug effects*, physiology Hypertension / chemically induced, enzymology* Isoenzymes / metabolism* Male Prostaglandin-Endoperoxide Synthases / metabolism* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; 11128-99-7/Angiotensin II; 52-39-1/Aldosterone; EC 1.14.99.1/Cyclooxygenase 2; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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