Document Detail


Analysis of angiotensin II mediated COX-2 downregulation in angiotensin II- or aldosterone-infused hypertensive rat.
MedLine Citation:
PMID:  12913255     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The renin-angiotensin cascade plays an important role in blood pressure control and sodium homeostasis. This study investigated whether cyclooxygenase-2 expression is regulated in the kidney, in an angiotensin II- and aldosterone-induced hypertension model. For this purpose, we treated male Sprague-Dawley rats (n=8 per group) with angiotensin II (9 mg/h, subcutaneously) for 14 d and aldosterone (0.75 mg/h, subcutaneously) for 42 d. Systolic blood pressure was significantly increased by angiotensin II (p<0.001) and by aldosterone (p<0.001). We found that angiotensin II downregulated cyclooxygenase-2 protein in the kidney cortex, whereas aldosterone showed no effect. These results indicate that angiotensin II may act directly to inhibit kidney cortex cyclooxygenase-2 protein expression, rather than acting via stimulation of aldosterone.
Authors:
Won Chung Lim; Jeong Bae Park; Young Joo Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  26     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-12     Completed Date:  2004-04-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1086-8     Citation Subset:  IM    
Affiliation:
College of Bioscience, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University.
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MeSH Terms
Descriptor/Qualifier:
Aldosterone / pharmacology*
Angiotensin II / pharmacology*
Animals
Blood Pressure / drug effects,  physiology
Cyclooxygenase 2
Down-Regulation / drug effects*,  physiology
Hypertension / chemically induced,  enzymology*
Isoenzymes / metabolism*
Male
Prostaglandin-Endoperoxide Synthases / metabolism*
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Isoenzymes; 11128-99-7/Angiotensin II; 52-39-1/Aldosterone; EC 1.14.99.1/Cyclooxygenase 2; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases

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