Document Detail

Analysis of altered capillary pressure and permeability after thermal injury.
MedLine Citation:
PMID:  3586633     Owner:  NLM     Status:  MEDLINE    
In order to investigate the effects of thermal injury on microvascular hemodynamics and permeability, hindpaw arterial (PA), venous (PV), and capillary (PC) pressures, blood (QB) and lymph (QL) flows, and lymph (CL) and plasma (CP) total protein concentrations were measured before and for 3 hr after a 10-sec 100 degrees C scald burn in 11 dogs. Prior to injury in eight experiments (Group I--permeability analysis) venous pressure was elevated by outflow restriction until the minimal CL/CP was obtained. In three experiments (Group II--hemodynamic analysis) outflow was not restricted. Lymph and plasma protein fractions ranging in size from 37 to 120 A were measured using gradient gel electrophoresis and capillary equivalent pore sizes were calculated. In the early postburn period, PC increased from 24 +/- 2 (mean +/- SE) to 47 +/- 5 mm Hg (P less than 0.05) and precapillary resistance (RA) decreased from 6.6 +/- 0.2 to 2.5 +/- 0.2 mm Hg/ml/min/100 g (P less than 0.05) while postcapillary resistance (RV) remained unchanged. Pre- to postcapillary resistance (RA/RV) fell by 74%. The reflection coefficient for total proteins (calculated as sigma = 1 - CL/CP) decreased from 0.87 +/- 0.01 to 0.45 +/- 0.02 (P less than 0.01). Permeability of the postburn capillary endothelium was described by using two populations of equivalent pores. Preburn pore radii were 50 and 300 A with 13% of the capillary filtrate passing through the large pores. Pore radii increased after injury to 70 and 400 A with 49% of the filtrate passing through the large pores. The postburn total tissue filtration coefficient (Kf) increased to 2.4 times the control. Over the first 3 hr postburn, 53% of the increase in capillary filtration was attributable to increased capillary pressure and 47% to increased permeability. We conclude that the early rapid edema formation following thermal injury is the result of marked increases in both capillary filtration pressure and filtration through large nonsieving pores.
R M Pitt; J C Parker; G J Jurkovich; A E Taylor; P W Curreri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of surgical research     Volume:  42     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-07-23     Completed Date:  1987-07-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  693-702     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Blood Proteins / metabolism
Burns / physiopathology*
Capillaries / physiopathology*
Capillary Permeability*
Lymph / metabolism,  physiology
Models, Cardiovascular
Osmotic Pressure
Proteins / metabolism
Reg. No./Substance:
0/Blood Proteins; 0/Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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