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Analysis of aggregate exposure to chlorpyrifos in the NHEXAS-Maryland investigation.
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MedLine Citation:
PMID:  11882473     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As part of the National Human Exposure Assessment Survey (NHEXAS) in Maryland, we collected indoor air, carpet dust, exterior soil, and duplicate diet samples from a stratified random sample of 80 individuals to evaluate aggregate daily exposure, contributions of specific pathways of exposure, and temporal variation in exposure to chlorpyrifos. We collected samples from each participant in up to six equally spaced sampling cycles over a year and analyzed them for chlorpyrifos. We used chlorpyrifos concentrations in each medium and self-reported rates of time spent inside at home, time and frequency of contact with carpet, frequency of contact with soil, and weights of the duplicate diet samples to derive exposure to chlorpyrifos from each medium as well as average daily aggregate exposure (nanograms per day). The mean aggregate daily exposure to chlorpyrifos of 36 measurements obtained from 31 people was 1,390 ng/day (SD, 2,770 ng/day). Exposure from inhalation of indoor air accounted for 84.7% of aggregate daily exposure to chlorpyrifos on average. Chlorpyrifos concentrations in indoor air and carpet dust and the corresponding exposure rates were significantly correlated. Repeated short-term measurements of chlorpyrifos in carpet dust from individual residences were strongly correlated over time (reliability coefficient, R = 0.90), whereas the short-term measurements of chlorpyrifos in indoor air (R = 0.55) and solid food (R = 0.03) had moderate to weak reliability. Exposure to chlorpyrifos through those media and in aggregate based on direct measurements reported in this study can be used to understand better the accuracy of pesticide safety assessments.
Authors:
Yaohong Pang; David L MacIntosh; David E Camann; P Barry Ryan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Environmental health perspectives     Volume:  110     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-07     Completed Date:  2002-06-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  United States    
Other Details:
Languages:  eng     Pagination:  235-40     Citation Subset:  IM    
Affiliation:
Department of Environmental Health Science, College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA 30602-2102, USA.
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MeSH Terms
Descriptor/Qualifier:
Activities of Daily Living
Air Pollution, Indoor / analysis*
Chlorpyrifos / analysis*
Dust
Environmental Exposure*
Environmental Monitoring*
Floors and Floorcoverings
Humans
Insecticides / analysis*
Maryland
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Dust; 0/Insecticides; 2921-88-2/Chlorpyrifos
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 3 Year: 2002
Volume: 110 Issue: 3
First Page: 235 Last Page: 240
ID: 1240762
PubMed Id: 11882473
Publisher Item Identifier: sc271_5_1835

Analysis of aggregate exposure to chlorpyrifos in the NHEXAS-Maryland investigation.
Yaohong Pang
David L MacIntosh
David E Camann
P Barry Ryan
Department of Environmental Health Science, College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA 30602-2102, USA.


Article Categories:
  • Research Article


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